INT192918

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Context Info
Confidence 0.57
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.29
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (HAMP) cytoplasm (HAMP)
HAMP (Homo sapiens)
Pain Link Frequency Relevance Heat
palliative 1 86.52 High High
cytokine 3 42.48 Quite Low
Inflammation 6 41.68 Quite Low
fibrosis 8 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Parenteral administration 1 5.00 Very Low Very Low Very Low
headache 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Toxicity 14 99.16 Very High Very High Very High
Leishmaniasis 1 98.44 Very High Very High Very High
Thalassemia 37 97.88 Very High Very High Very High
Immunotherapy Of Cancer 1 96.52 Very High Very High Very High
Lymphatic System Cancer 1 90.80 High High
Breast Cancer 1 88.68 High High
Metastasis 1 88.00 High High
Sickle Cell Anemia 86 84.80 Quite High
Anaemia 20 83.48 Quite High
Hemolysis 3 78.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, hepcidin is significantly downregulated in patients with ineffective erythropoiesis such as thalassemia, thereby worsening unbound iron toxicity in this population [56–58].
Negative_regulation (downregulated) of hepcidin associated with toxicity and thalassemia
1) Confidence 0.57 Published 2010 Journal Advances in Hematology Section Body Doc Link PMC2872757 Disease Relevance 1.42 Pain Relevance 0
Dose escalation of orally given HePC is prevented by gastrointestinal toxicity.
Negative_regulation (prevented) of HePC associated with toxicity
2) Confidence 0.16 Published 2006 Journal Radiat Oncol Section Body Doc Link PMC1475859 Disease Relevance 0.87 Pain Relevance 0.09
TMPRSS6 auto-activation is critical for protein function because transfection of TMPRSS6(Y141C) fails to attenuate hepcidin promoter activity (Figure 7).
Negative_regulation (attenuate) of hepcidin
3) Confidence 0.15 Published 2010 Journal Biochemical Journal Section Body Doc Link PMC2958558 Disease Relevance 0 Pain Relevance 0

General Comments

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