INT19292

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Context Info
Confidence 0.76
First Reported 1991
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 0.80
Pain Relevance 2.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CALCA) aging (CALCA) extracellular region (CALCA)
nucleus (CALCA) intracellular (CALCA) cell-cell signaling (CALCA)
Anatomy Link Frequency
vas deferens 3
cleavage 1
skin 1
CALCA (Homo sapiens)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 22 100.00 Very High Very High Very High
metalloproteinase 15 99.94 Very High Very High Very High
allodynia 2 96.64 Very High Very High Very High
qutenza 9 96.52 Very High Very High Very High
Hyperalgesia 2 96.08 Very High Very High Very High
antagonist 4 95.80 Very High Very High Very High
Pain 3 93.76 High High
Migraine 1 92.16 High High
reflex sympathetic dystrophy 1 91.20 High High
Potency 1 84.48 Quite High
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 3 99.44 Very High Very High Very High
Neuropathic Pain 2 96.64 Very High Very High Very High
Hyperalgesia 2 96.08 Very High Very High Very High
Neurogenic Inflammation 3 75.00 Quite High
Pain 1 5.00 Very Low Very Low Very Low
Headache 1 5.00 Very Low Very Low Very Low
Complex Regional Pain Syndromes 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The C-terminal fragment of the human alpha-calcitonin gene-related peptide (hCGRP), hCGRP-(8-37) competitively antagonized both the positive inotropic effect of hCGRP in the guinea-pig isolated left atria (pA2 6.89) and the smooth muscle relaxant effect of hCGRP in the rat isolated vas deferens (pA2 6.55) but left the response to isoprenaline unaffected in both preparations.
Protein_catabolism (effect) of hCGRP in vas deferens associated with calcitonin gene-related peptide
1) Confidence 0.76 Published 1991 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2040366 Disease Relevance 0 Pain Relevance 0.24
The C-terminal fragment of the human alpha-calcitonin gene-related peptide (hCGRP), hCGRP-(8-37) competitively antagonized both the positive inotropic effect of hCGRP in the guinea-pig isolated left atria (pA2 6.89) and the smooth muscle relaxant effect of hCGRP in the rat isolated vas deferens (pA2 6.55) but left the response to isoprenaline unaffected in both preparations.
Protein_catabolism (effect) of hCGRP in vas deferens associated with calcitonin gene-related peptide
2) Confidence 0.76 Published 1991 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2040366 Disease Relevance 0 Pain Relevance 0.24
The C-terminal fragment of the human alpha-calcitonin gene-related peptide (hCGRP), hCGRP-(8-37) competitively antagonized both the positive inotropic effect of hCGRP in the guinea-pig isolated left atria (pA2 6.89) and the smooth muscle relaxant effect of hCGRP in the rat isolated vas deferens (pA2 6.55) but left the response to isoprenaline unaffected in both preparations.
Protein_catabolism (effect) of alpha-calcitonin gene-related peptide in vas deferens associated with calcitonin gene-related peptide
3) Confidence 0.76 Published 1991 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2040366 Disease Relevance 0 Pain Relevance 0.24
The concentration of CGRP was significantly higher in the pulps of smokers compared with non-smokers (P = 0.02).
Protein_catabolism (concentration) of CGRP
4) Confidence 0.57 Published 2002 Journal Int Endod J Section Body Doc Link 11853236 Disease Relevance 0 Pain Relevance 0
Capillary electrophoresis in citrate buffer was also successful in the separation of the four final trypsin cleavage fragments of salmon calcitonin and, at least tentatively, of the nine intermediate cleavage products.
Protein_catabolism (cleavage) of calcitonin in cleavage
5) Confidence 0.54 Published 1994 Journal J. Chromatogr. B, Biomed. Appl. Section Abstract Doc Link 7952019 Disease Relevance 0 Pain Relevance 0
We conclude that vascular MMP-2 cleaves endogenous CGRP and promotes vasoconstriction.
Protein_catabolism (cleaves) of CGRP associated with metalloproteinase, increased venous pressure under development and calcitonin gene-related peptide
6) Confidence 0.53 Published 2000 Journal Circ. Res. Section Abstract Doc Link 11029402 Disease Relevance 0.17 Pain Relevance 1.07
Our findings suggest that NEP but not ACE is most important for CGRP degradation in human skin.
Protein_catabolism (degradation) of CGRP in skin
7) Confidence 0.49 Published 2005 Journal Exp. Neurol. Section Abstract Doc Link 15963503 Disease Relevance 0.63 Pain Relevance 0.75

General Comments

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