INT19293

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Context Info
Confidence 0.95
First Reported 1991
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 5.15
Pain Relevance 2.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (FN1) extracellular region (FN1) cell adhesion (FN1)
proteinaceous extracellular matrix (FN1)
Anatomy Link Frequency
cartilage 2
uterine 1
FN1 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 155 99.96 Very High Very High Very High
Snapping jaw 12 94.72 High High
Osteoarthritis 2 92.40 High High
Chronic pancreatitis 33 91.48 High High
cytokine 42 83.96 Quite High
Inflammation 47 77.28 Quite High
fibrosis 8 75.00 Quite High
palliative 1 25.00 Low Low
Pain 3 20.32 Low Low
Inflammatory mediators 3 8.32 Low Low
Disease Link Frequency Relevance Heat
Injury 79 100.00 Very High Very High Very High
Wound Healing 5 97.88 Very High Very High Very High
Primary Sclerosing Cholangitis 77 97.16 Very High Very High Very High
Breast Cancer 4 96.92 Very High Very High Very High
Cancer 14 95.24 Very High Very High Very High
Temporomandibular Joint Syndrome 12 94.72 High High
Osteoarthritis 2 92.40 High High
Nicotine Addiction 1 92.28 High High
Pancreatitis 33 91.48 High High
Solid Tumor 2 89.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Native fibronectin has been shown to assist with wound repair, whereas particular fibronectin fragments may degrade cartilage.
Protein_catabolism (degrade) of fibronectin in cartilage associated with injury
1) Confidence 0.95 Published 2009 Journal J. Oral Maxillofac. Surg. Section Abstract Doc Link 19070755 Disease Relevance 0.80 Pain Relevance 0.56
Native fibronectin has been shown to assist with wound repair, whereas particular fibronectin fragments may degrade cartilage.
Protein_catabolism (degrade) of fibronectin in cartilage associated with injury
2) Confidence 0.63 Published 2009 Journal J. Oral Maxillofac. Surg. Section Abstract Doc Link 19070755 Disease Relevance 0.81 Pain Relevance 0.56
Matrix metalloproteinase-7 (MMP7, matrilysin or uterine metalloproteinase) degrades casein, fibronectin and gelatin types I, III, IV and V [21].
Protein_catabolism (degrades) of fibronectin in uterine associated with metalloproteinase
3) Confidence 0.23 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2805671 Disease Relevance 0.10 Pain Relevance 0.10
Substances with both procoagulant activity and fibrinolytic activity are important factors in the formation or degradation of a "fibrin-fibronectin-gel matrix".
Protein_catabolism (degradation) of fibronectin
4) Confidence 0.20 Published 1991 Journal Geburtshilfe Frauenheilkd Section Abstract Doc Link 2040418 Disease Relevance 0.56 Pain Relevance 0
LPS and TNFalpha induced collagen1 and fibronectin levels as well as the matrix degradation enzyme MMP-1.
Protein_catabolism (degradation) of fibronectin
5) Confidence 0.19 Published 2007 Journal J Transl Med Section Abstract Doc Link PMC2234395 Disease Relevance 1.64 Pain Relevance 0.89
MMP-12 degrades a broad range of ECM proteins, including elastin, type IV collagen, fibronectin, laminin and gelatin [8,9], and is involved in turnover of the matrix, cell migration, tissue repairing and remodeling.
Protein_catabolism (degrades) of fibronectin associated with metalloproteinase
6) Confidence 0.15 Published 2005 Journal Respir Res Section Body Doc Link PMC1363355 Disease Relevance 0.61 Pain Relevance 0.81
A chymotrypsin-like serine proteinase exhibited excellent degradation of ECM components laminin, fibronectin, and collagen types I and III (26), and may therefore play a significant role in the digestion of wound matrix and effective debridement.
Protein_catabolism (degradation) of fibronectin associated with injury
7) Confidence 0.03 Published 2006 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1475942 Disease Relevance 0.63 Pain Relevance 0.05

General Comments

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