INT192937

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Context Info
Confidence 0.67
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 0.40
Pain Relevance 0.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (GJA1) Golgi apparatus (GJA1) endoplasmic reticulum (GJA1)
cell-cell signaling (GJA1) cytoplasm (GJA1) signal transducer activity (GJA1)
Anatomy Link Frequency
myometrium 4
myocyte 2
GJA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dismenorea 23 82.88 Quite High
Action potential 4 78.12 Quite High
antagonist 12 5.00 Very Low Very Low Very Low
agonist 10 5.00 Very Low Very Low Very Low
withdrawal 6 5.00 Very Low Very Low Very Low
Kinase C 3 5.00 Very Low Very Low Very Low
iatrogenic 2 5.00 Very Low Very Low Very Low
potassium channel 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
cva 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Dysmenorrhea 23 82.88 Quite High
Targeted Disruption 2 13.32 Low Low
Emergencies 7 5.00 Very Low Very Low Very Low
Premature Birth 6 5.00 Very Low Very Low Very Low
Anencephaly 4 5.00 Very Low Very Low Very Low
Overactive Bladder 3 5.00 Very Low Very Low Very Low
Hypertrophy 3 5.00 Very Low Very Low Very Low
Abruptio Placentae 3 5.00 Very Low Very Low Very Low
Disease 3 5.00 Very Low Very Low Very Low
Endometriosis (extended) 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our findings with antibody directed against total connexin 43 are consistent with the increased expression of connexin 43 in the myometrium around the time of labour although it can also be seen that connexin 43 is also present at times other than labour.
Positive_regulation (increased) of Gene_expression (expression) of connexin 43 in myometrium
1) Confidence 0.67 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2553078 Disease Relevance 0.21 Pain Relevance 0.25
Retinoic acid upregulates GJA1 expression in human endometrial and myometrial cells probably through nuclear receptors [37,38].
Positive_regulation (upregulates) of Gene_expression (expression) of GJA1
2) Confidence 0.65 Published 2007 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC1892059 Disease Relevance 0 Pain Relevance 0
It is observed that connexin 43 expression is greatly increased at the time of parturition and it has been proposed that this connexin, in the form of gap junctions, leads to the formation of a 'functional syncytium' providing for the coordination of contractions throughout the myometrium [3].
Positive_regulation (increased) of Gene_expression (expression) of connexin 43 in myometrium
3) Confidence 0.45 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2553078 Disease Relevance 0 Pain Relevance 0
GJA1 (connexin 43) is one of the main structural proteins in myometrial gap junctions; its expression is stimulated by oestradiol and inhibited by progesterone [34].
Positive_regulation (stimulated) of Gene_expression (expression) of GJA1
4) Confidence 0.41 Published 2007 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC1892059 Disease Relevance 0 Pain Relevance 0
The levels of Connexin 43 mRNA expression showed a tendency to increase at labour.
Positive_regulation (increase) of Gene_expression (expression) of Connexin 43 mRNA
5) Confidence 0.04 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1475867 Disease Relevance 0 Pain Relevance 0
There is a large amount of supportive evidence related to this showing increased levels of connexin 43 protein and increased numbers of gap junctions on the smooth myocyte cell membrane associated with parturition.
Positive_regulation (increased) of Gene_expression (levels) of connexin 43 protein in myocyte
6) Confidence 0.02 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2553078 Disease Relevance 0.19 Pain Relevance 0.19

General Comments

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