INT192957

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Context Info
Confidence 0.69
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.19
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (KIT) extracellular space (KIT) plasma membrane (KIT)
nucleus (KIT) cytoplasm (KIT)
KIT (Homo sapiens)
Pain Link Frequency Relevance Heat
sodium channel 3 89.88 High High
cytokine 16 84.08 Quite High
cva 50 81.76 Quite High
Hippocampus 11 77.84 Quite High
chemokine 20 50.00 Quite Low
Neuronal excitability 1 50.00 Quite Low
imagery 2 24.48 Low Low
Pain 17 5.00 Very Low Very Low Very Low
Action potential 17 5.00 Very Low Very Low Very Low
Inflammation 15 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Seminoma 1 99.04 Very High Very High Very High
Malignant Fibrous Histiocytoma 1 98.68 Very High Very High Very High
Germ Cell And Embryonal Neoplasms 1 98.00 Very High Very High Very High
Cancer 90 96.24 Very High Very High Very High
Thyroid Neoplasm 3 95.84 Very High Very High Very High
Piebaldism 1 91.56 High High
Disease 16 90.88 High High
Apoptosis 27 87.24 High High
Hemangiosarcoma 2 83.12 Quite High
Cv General 4 Under Development 41 81.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For fluorescence labeling of target cDNAs, 20 µg of total RNA from universal human reference (Strategene, USA) and experiment samples (RNA extracted from infected cells using Qiagen RNeasy Mini Kit ) were reverse transcribed in the presence of Cy3-dUTP and Cy5-dUTP (Amersham Biosciences, UK) using the Superscript reverse transcription kit (Invitrogen, USA).
Transcription (transcribed) of Kit
1) Confidence 0.69 Published 2007 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2100376 Disease Relevance 0.05 Pain Relevance 0
Immediately after isolation, RNA was transcribed into cDNA using an iScript cDNA kit (Bio-Rad).
Transcription (transcribed) of kit
2) Confidence 0.69 Published 2008 Journal Mol Pain Section Body Doc Link PMC2562993 Disease Relevance 0 Pain Relevance 0.04
Although an over-expression of CD117 mRNA was noted in cell lines of malignant fibrous histiocytomas [36], IHC evaluation of such tumors for c-kit revealed only one positive reaction out of 43 cases [51].
Transcription (expression) of CD117 associated with malignant fibrous histiocytoma and cancer
3) Confidence 0.53 Published 2006 Journal Diagn Pathol Section Body Doc Link PMC1475889 Disease Relevance 1.37 Pain Relevance 0
The upregulation of these miRNAs was strongest associated with a dramatic loss of Kit transcript and its protein.
Transcription (transcript) of Kit
4) Confidence 0.29 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2098778 Disease Relevance 0.57 Pain Relevance 0
In addition to growth factors, the RT-PCR study has demonstrated that both primary human MSCs and B10 cells express mRNA for VEGFR, CXCR4 and c-kit, cellular receptors known for close involvement in cellular migration (Figure 10).
Transcription (express) of c-kit
5) Confidence 0.22 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2092394 Disease Relevance 0.20 Pain Relevance 0.18

General Comments

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