INT192958

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Context Info
Confidence 0.30
First Reported 2006
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 6.35
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (IGF1R) plasma membrane (IGF1R)
Anatomy Link Frequency
neck 1
plaque 1
skin 1
head 1
lung 1
IGF1R (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 2 97.88 Very High Very High Very High
Somatostatin 2 97.04 Very High Very High Very High
Bioavailability 1 90.24 High High
Inflammation 14 67.20 Quite High
Angina 5 5.00 Very Low Very Low Very Low
alcohol 4 5.00 Very Low Very Low Very Low
palliative 4 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
methotrexate 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 36 100.00 Very High Very High Very High
Shock 1 100.00 Very High Very High Very High
Neuroendocrine Cancer 7 99.76 Very High Very High Very High
Small Cell Lung Carcinoma 1 98.92 Very High Very High Very High
Head & Neck Cancer 10 98.44 Very High Very High Very High
Cancer 268 93.86 High High
Pancreatic Cancer 12 93.84 High High
Acute Myeloid Leukemia 3 93.36 High High
Hyperinsulinism 1 92.36 High High
Gastrointestinal Stromal Tumor 9 90.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In their analysis of 105 patients, a clear genotypic profile emerged which correlated with an adverse outcome and could potentially be targeted by IGF1R inhibitors.


Negative_regulation (inhibitors) of IGF1R
1) Confidence 0.30 Published 2010 Journal J Hematol Oncol Section Body Doc Link PMC2856525 Disease Relevance 1.12 Pain Relevance 0.05
Future directions of research in HER2-positive gastroesophageal cancer should focus on the evaluation of novel antibodies (such as pertuzumab, a dimerization inhibitor, and T-DM1, a drug that combines trastuzumab with a linked chemotherapy agent called maytansine), irreversible tyrosine kinase inhibitors (such as neratinib and BIBW 2992, both dual EGFR-HER2 inhibitors), and inhibitors of HER2-related downstream signaling (such as mammalian target of rapamycin (mTOR), heat shock protein 90 (Hsp90), and PI3K/Akt) and of receptor crosstalk (such as other HER family members, vascular endothelial growth factor receptor (VEGFR), and insulin-like growth factor receptor (IGFR)).
Negative_regulation (inhibitors) of IGFR associated with cancer and shock
2) Confidence 0.20 Published 2011 Journal Pathology Research International Section Body Doc Link PMC3005843 Disease Relevance 0.71 Pain Relevance 0
In particular, inhibition of IGF-1R is actively being studied in head and neck cancer.
Negative_regulation (inhibition) of IGF-1R in head associated with head & neck cancer
3) Confidence 0.19 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2921255 Disease Relevance 0.55 Pain Relevance 0
Low dose of ssUV was shown in this study to downregulate apoptotic genes BCL2, TP53, IGF1R, PRKCA, and AKT1, which are also involved in the regulation of telomerase activity, and thought to play important roles in the initiation of skin carcinogenesis [63, 146].
Negative_regulation (downregulate) of IGF1R in skin associated with apoptosis
4) Confidence 0.13 Published 2010 Journal Journal of Nucleic Acids Section Body Doc Link PMC2915624 Disease Relevance 1.21 Pain Relevance 0.03
Okura et al. (2001) and Patel et al. (2001) [13, 14] described reduction of local IGF-1, IGFR in advanced plaque, possibly due to proinflammatory cytokines, and ox-LDL effect.
Spec (possibly) Negative_regulation (reduction) of IGFR in plaque associated with cytokine
5) Confidence 0.12 Published 2010 Journal Protein J Section Body Doc Link PMC2992669 Disease Relevance 0.47 Pain Relevance 0.09
In particular, inhibition of IGF-1R is actively being studied in head and neck cancer.
Negative_regulation (inhibition) of IGF-1R in neck associated with head & neck cancer
6) Confidence 0.06 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2921255 Disease Relevance 0.55 Pain Relevance 0
The same method was used to test for a decrease in IGF-1R with the lycopene supplement without any adjustment for multiple testing.
Negative_regulation (decrease) of IGF-1R
7) Confidence 0.05 Published 2010 Journal Cancer Causes Control Section Body Doc Link PMC3002170 Disease Relevance 0 Pain Relevance 0
Combined therapy with IGF-1R inhibitors or inhibitors of PI3K and AKT may therefore be useful.45–47 More studies looking into the mechanisms of resistance to these compounds need to be done as our experience with this agent increases.



Negative_regulation (inhibitors) of IGF-1R
8) Confidence 0.03 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004583 Disease Relevance 0.23 Pain Relevance 0
In vitro studies of small cell lung carcinoma cell lines showed a synergistic effect for c-kit and IGF-1R inhibitors in the induction of apoptosis [9,48].
Negative_regulation (inhibitors) of IGF-1R in lung associated with small cell lung carcinoma and apoptosis
9) Confidence 0.03 Published 2006 Journal Diagn Pathol Section Body Doc Link PMC1475889 Disease Relevance 1.51 Pain Relevance 0.03

General Comments

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