INT192962

Context Info Confidence 0.46 First Reported 2006 Last Reported 2006 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 2.74 Pain Relevance 0

signal transduction (KIT) extracellular space (KIT) plasma membrane (KIT) nucleus (KIT) cytoplasm (KIT)

KIT (Homo sapiens)

Pain Link Frequency Relevance Heat cytokine 2 5.00 Pain 2 5.00

Disease Link Frequency Relevance Heat Seminoma 2 99.24 Malignant Fibrous Histiocytoma 2 98.68 Germ Cell And Embryonal Neoplasms 2 98.20 Cancer 76 96.24 Piebaldism 2 91.76 Disease 6 91.08 Apoptosis 26 87.44 Hemangiosarcoma 4 83.32 Leiomyosarcoma 2 80.64 Adhesions 2 71.64

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Although an over-expression of CD117 mRNA was noted in cell lines of malignant fibrous histiocytomas [36], IHC evaluation of such tumors for c-kit revealed only one positive reaction out of 43 cases [51].

Positive_regulation (-) of Transcription (expression) of CD117 associated with malignant fibrous histiocytoma and cancer

1) Confidence 0.46 Published 2006 Journal Diagn Pathol Section Body Doc Link PMC1475889 Disease Relevance 1.37 Pain Relevance 0

Although an over-expression of CD117 mRNA was noted in cell lines of malignant fibrous histiocytomas [36], IHC evaluation of such tumors for c-kit revealed only one positive reaction out of 43 cases [51].

Positive_regulation (over) of Transcription (expression) of CD117 associated with malignant fibrous histiocytoma and cancer

2) Confidence 0.46 Published 2006 Journal Diagn Pathol Section Body Doc Link PMC1475889 Disease Relevance 1.37 Pain Relevance 0

General Comments

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