INT192964

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Context Info
Confidence 0.28
First Reported 2006
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 2.00
Pain Relevance 2.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Hp) extracellular region (Hp) Golgi apparatus (Hp)
endoplasmic reticulum (Hp)
Anatomy Link Frequency
liver 1
Hp (Mus musculus)
Pain Link Frequency Relevance Heat
antiallodynic 171 99.98 Very High Very High Very High
dexamethasone 21 98.96 Very High Very High Very High
Morphine 21 96.62 Very High Very High Very High
narcan 30 95.50 Very High Very High Very High
agonist 60 94.48 High High
Potency 17 92.96 High High
Arthritis 27 92.64 High High
Inflammation 63 90.36 High High
cytokine 6 89.28 High High
Clonidine 33 89.20 High High
Disease Link Frequency Relevance Heat
Pressure And Volume Under Development 63 96.48 Very High Very High Very High
Arthritis 24 92.64 High High
INFLAMMATION 69 90.36 High High
Neuroblastoma 6 75.60 Quite High
Prostate Or Kidney Disorder 3 58.32 Quite High
Weight Loss 3 54.36 Quite High
Body Weight 3 54.16 Quite High
Hypersensitivity 75 50.00 Quite Low
Targeted Disruption 41 50.00 Quite Low
Cancer 9 47.52 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Measurement of Haptoglobin
Positive_regulation (Measurement) of Haptoglobin
1) Confidence 0.28 Published 2006 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1475933 Disease Relevance 0.41 Pain Relevance 0.07
We also used naloxone hydrochloride (Sigma-Aldrich QuĂ­mica S.A.) and morphine hydrochloride (General Directorate of Pharmacy and Drugs, Spanish Ministry of Health) to evaluate the involvement of opioidergic system modulation in the antiallodynic effect of HP and its metabolites.
Positive_regulation (effect) of HP associated with narcan, antiallodynic and morphine
2) Confidence 0.26 Published 2009 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2695546 Disease Relevance 0.13 Pain Relevance 0.87
Therefore, the antiallodynic effects of HP and its metabolites might be explained by their ability to indirectly modulate NMDA-mediated effects through an action on ?
Positive_regulation (effects) of HP associated with antiallodynic
3) Confidence 0.26 Published 2009 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2695546 Disease Relevance 0 Pain Relevance 0.53
In contrast, there are several arguments indicating that the antiallodynic effects of HP and its metabolites are due to their activity on ?
Positive_regulation (effects) of HP associated with antiallodynic
4) Confidence 0.26 Published 2009 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2695546 Disease Relevance 0.08 Pain Relevance 0.58
Transcription of the haptoglobin gene is enhanced through multiple IL-6 response elements, and haptoglobin increases in the liver and serum (23).
Positive_regulation (increases) of haptoglobin in liver
5) Confidence 0.26 Published 2006 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1475933 Disease Relevance 0.75 Pain Relevance 0.51
1) also did not reduce serum haptoglobin significantly either.


Neg (not) Positive_regulation (reduce) of serum haptoglobin
6) Confidence 0.24 Published 2006 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1475933 Disease Relevance 0.63 Pain Relevance 0.19
The HP-SEC peaks (D) are numbered from 1 to 4 (see text for details), with the vertical dashed lines showing the range of each peak.
Positive_regulation (numbered) of HP-SEC
7) Confidence 0.02 Published 2010 Journal Pharm Res Section Body Doc Link PMC2916121 Disease Relevance 0 Pain Relevance 0

General Comments

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