INT192967

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Context Info
Confidence 0.43
First Reported 2006
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 14
Total Number 14
Disease Relevance 8.06
Pain Relevance 11.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Hp) extracellular region (Hp) Golgi apparatus (Hp)
endoplasmic reticulum (Hp)
Anatomy Link Frequency
liver 2
spinal 1
Hp (Mus musculus)
Pain Link Frequency Relevance Heat
antiallodynic 570 99.98 Very High Very High Very High
antagonist 220 99.84 Very High Very High Very High
dexamethasone 21 99.44 Very High Very High Very High
Morphine 70 99.20 Very High Very High Very High
central pain 10 99.10 Very High Very High Very High
Arthritis 27 98.96 Very High Very High Very High
qutenza 590 98.56 Very High Very High Very High
narcan 100 98.18 Very High Very High Very High
Pain 130 98.08 Very High Very High Very High
allodynia 130 97.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 130 99.10 Very High Very High Very High
Arthritis 24 98.96 Very High Very High Very High
Hypersensitivity 243 98.60 Very High Very High Very High
Hemolysis 29 97.92 Very High Very High Very High
Neuropathic Pain 140 97.72 Very High Very High Very High
INFLAMMATION 83 97.56 Very High Very High Very High
Targeted Disruption 10 95.84 Very High Very High Very High
Pressure And Volume Under Development 63 92.52 High High
Paroxysmal Nocturnal Hemoglobinuria 97 90.84 High High
Weight Loss 3 89.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Each class of anti-inflammatory drugs has a specific effect on the regulation of acute phase proteins (16), and dexamethasone is known not to reduce the haptoglobin expression (17).
Gene_expression (expression) of haptoglobin associated with inflammation, cinod and dexamethasone
1) Confidence 0.43 Published 2006 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1475933 Disease Relevance 1.05 Pain Relevance 0.59
Transcription of the haptoglobin gene is enhanced through multiple IL-6 response elements, and haptoglobin increases in the liver and serum (23).
Gene_expression (increases) of haptoglobin in liver
2) Confidence 0.37 Published 2006 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1475933 Disease Relevance 0.75 Pain Relevance 0.51
The main aim of this study was to evaluate the effects of the sigma ligands HP and its metabolites on mechanical hypersensitivity induced by the intraplantar injection of capsaicin and to determine whether these effects are due to their antagonism of ?
Gene_expression (evaluate) of HP associated with qutenza and hypersensitivity
3) Confidence 0.35 Published 2009 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2695546 Disease Relevance 0.64 Pain Relevance 1.02
Higher doses of HP and HP-Met-II (that produced 100% of the antiallodynic effect) affected the response in the rotarod test, but these motor effects were not reversed by PRE-084 (i.e., were not due to antagonism of ?
Gene_expression (doses) of HP-Met associated with antiallodynic
4) Confidence 0.35 Published 2009 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2695546 Disease Relevance 0 Pain Relevance 0.52
1 receptor antagonist BD-1063 (Matsumoto et al. 1995; Hayashi and Su 2004) produced a response pattern very similar to that of HP and its metabolites, i.e., an antiallodynic effect that was fully reversed by the ?
Gene_expression (produced) of HP associated with antagonist and antiallodynic
5) Confidence 0.35 Published 2009 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2695546 Disease Relevance 0.14 Pain Relevance 1.00
Since we administered the drugs subcutaneously, our data do not shed light on the level of central pain processing (spinal or supraspinal) at which HP and its metabolites produce their antiallodynic effects, and new experiments will be needed to identify their level of action.
Gene_expression (produce) of HP in spinal associated with pain, central pain and antiallodynic
6) Confidence 0.35 Published 2009 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2695546 Disease Relevance 0.49 Pain Relevance 0.90
We found that a dose of naloxone that reversed the antiallodynic effect of morphine was unable to modify the antiallodynic effects of HP and its metabolites.
Gene_expression (effects) of HP associated with narcan, antiallodynic and morphine
7) Confidence 0.35 Published 2009 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2695546 Disease Relevance 0.23 Pain Relevance 1.28
Interestingly, this dose of HP occupies more ?
Gene_expression (dose) of HP
8) Confidence 0.35 Published 2009 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2695546 Disease Relevance 0.52 Pain Relevance 0.89
1 receptor antagonists HP and reduced HP (Cendán et al. 2005b).
Gene_expression (reduced) of HP associated with antagonist
9) Confidence 0.35 Published 2009 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2695546 Disease Relevance 0.72 Pain Relevance 1.31
It is noteworthy that the antiallodynic effect of HP is produced at a range of doses similar to those producing positive effects in animal models predictive of antipsychotic activity (Natesan et al. 2008; Millan et al. 2008).
Gene_expression (produced) of HP associated with antiallodynic
10) Confidence 0.35 Published 2009 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2695546 Disease Relevance 0.43 Pain Relevance 1.28
Therefore, HP and its metabolites might act at any of these sites to produce their antiallodynic effects.
Gene_expression (produce) of HP associated with antiallodynic
11) Confidence 0.35 Published 2009 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2695546 Disease Relevance 0.42 Pain Relevance 0.88
Higher doses of HP and HP-Met-II (that produced 100% of the antiallodynic effect) affected the response in the rotarod test, but these motor effects were not reversed by PRE-084 (i.e., were not due to antagonism of ?
Gene_expression (doses) of HP associated with antiallodynic
12) Confidence 0.35 Published 2009 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2695546 Disease Relevance 0 Pain Relevance 0.52
Serum haptoglobin was significantly reduced in a CP extract-treated group (inhibition rate: 72.5%) and CK extract-treated one (inhibition rate: 59.9%); however, no significant reduction was seen in other Curcuma drug extract-treated groups.
Gene_expression (reduced) of Serum haptoglobin
13) Confidence 0.32 Published 2006 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1475933 Disease Relevance 1.06 Pain Relevance 0.28
Haptoglobin, a protein produced mainly by hepatocytes in the liver, rapidly binds free hemoglobin and this haptoglobin–hemoglobin complex is then degraded in the liver.
Gene_expression (produced) of Haptoglobin in liver
14) Confidence 0.05 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2789686 Disease Relevance 1.60 Pain Relevance 0.05

General Comments

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