INT192970

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Context Info
Confidence 0.22
First Reported 2006
Last Reported 2009
Negated 2
Speculated 0
Reported most in Body
Documents 7
Total Number 9
Disease Relevance 6.99
Pain Relevance 4.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Hp) extracellular region (Hp) Golgi apparatus (Hp)
endoplasmic reticulum (Hp)
Hp (Mus musculus)
Pain Link Frequency Relevance Heat
Arthritis 45 99.84 Very High Very High Very High
dexamethasone 35 99.82 Very High Very High Very High
antagonist 66 99.28 Very High Very High Very High
nMDA receptor 24 99.08 Very High Very High Very High
cytokine 30 98.16 Very High Very High Very High
antiallodynic 171 96.60 Very High Very High Very High
cINOD 6 96.40 Very High Very High Very High
Inflammation 154 94.80 High High
Neuropathic pain 3 93.84 High High
Hyperalgesia 3 90.00 High High
Disease Link Frequency Relevance Heat
Pressure And Volume Under Development 105 99.92 Very High Very High Very High
Arthritis 40 99.84 Very High Very High Very High
INFLAMMATION 195 98.96 Very High Very High Very High
Neuropathic Pain 42 93.84 High High
Hyperalgesia 3 90.00 High High
Weight Loss 5 89.16 High High
Body Weight 5 88.96 High High
Pain 39 87.48 High High
Prostate Or Kidney Disorder 5 86.60 High High
Headache 3 85.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, a direct effect of HP or its metabolites on NMDA receptors might be ruled out as an explanation for their antiallodynic effect in the present study.
Negative_regulation (effect) of HP associated with nmda receptor and antiallodynic
1) Confidence 0.22 Published 2009 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2695546 Disease Relevance 0.14 Pain Relevance 0.79
Among the antipsychotics, haloperidol (HP) is mainly known as a D2 receptor antagonist, although it shows the same affinity for D2 and ?
Negative_regulation (known) of HP associated with antagonist
2) Confidence 0.22 Published 2009 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2695546 Disease Relevance 0 Pain Relevance 0.28
In fact, a dose of 3 mg HP occupied around 80% of ?
Negative_regulation (dose) of HP
3) Confidence 0.22 Published 2009 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2695546 Disease Relevance 0.54 Pain Relevance 0.91
Serum haptoglobin was slightly reduced in CP and CK extracts-treated groups, but not significantly.
Neg (not) Negative_regulation (reduced) of Serum haptoglobin
4) Confidence 0.21 Published 2006 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1475933 Disease Relevance 0.73 Pain Relevance 0.22
Since the methanol extract of CP reduced serum haptoglobin in arthritis, it may inhibit anywhere in the cytokine pathway.
Negative_regulation (reduced) of serum haptoglobin associated with cytokine and arthritis
5) Confidence 0.21 Published 2006 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1475933 Disease Relevance 0.85 Pain Relevance 0.51
Serum haptoglobin was significantly reduced in a CP extract-treated group (inhibition rate: 72.5%) and CK extract-treated one (inhibition rate: 59.9%); however, no significant reduction was seen in other Curcuma drug extract-treated groups.
Negative_regulation (reduced) of Serum haptoglobin
6) Confidence 0.21 Published 2006 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1475933 Disease Relevance 1.06 Pain Relevance 0.28
Dexamethasone did not inhibit the serum haptoglobin concentration (Figs 1 and 2).
Negative_regulation (inhibit) of serum haptoglobin associated with dexamethasone
7) Confidence 0.21 Published 2006 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1475933 Disease Relevance 1.17 Pain Relevance 0.61
1) did not reduce serum haptoglobin.
Neg (not) Negative_regulation (reduce) of serum haptoglobin
8) Confidence 0.20 Published 2006 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1475933 Disease Relevance 0.98 Pain Relevance 0.29
Use of antiinflammatory drugs in combination with scaling and root planing reduced CRP and haptoglobin in one study (Ebersole et al 1997) and in another study antiinfective drugs in combination with scaling and root planing reduced CRP, especially among those with elevated baseline CRP (Mattila et al 2002).
Negative_regulation (reduced) of haptoglobin associated with inflammation
9) Confidence 0.01 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2626915 Disease Relevance 1.53 Pain Relevance 0.16

General Comments

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