INT19300

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Context Info
Confidence 0.43
First Reported 1988
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 34
Total Number 35
Disease Relevance 4.43
Pain Relevance 4.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (OXT) extracellular space (OXT) extracellular region (OXT)
response to stress (OXT) cytoplasm (OXT)
Anatomy Link Frequency
plasma 10
neurons 3
hypothalamus 2
face 2
uterine 2
OXT (Homo sapiens)
Pain Link Frequency Relevance Heat
narcan 14 99.98 Very High Very High Very High
Dismenorea 42 99.60 Very High Very High Very High
Onset of action 4 98.16 Very High Very High Very High
Neuropeptide 396 97.88 Very High Very High Very High
agonist 101 97.88 Very High Very High Very High
Central nervous system 88 96.20 Very High Very High Very High
Sumatriptan 4 95.84 Very High Very High Very High
Endogenous opioid 3 93.04 High High
Rostral ventrolateral medulla 22 92.92 High High
Potency 7 90.32 High High
Disease Link Frequency Relevance Heat
Dysmenorrhea 36 99.60 Very High Very High Very High
Pre-term Labor 81 99.56 Very High Very High Very High
Nicotine Addiction 27 97.84 Very High Very High Very High
Premature Birth 55 96.56 Very High Very High Very High
Pressure Volume 2 Under Development 46 95.04 Very High Very High Very High
Pressure And Volume Under Development 22 92.04 High High
Anxiety Disorder 14 91.12 High High
Amnesia 7 87.76 High High
Reprotox - General 1 11 78.52 Quite High
Hypoglycemia 4 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
At the onset of labour both preterm and at term no marked increase in the OT receptor concentration was observed, but OT may still be involved in the initiation of labour, being produced locally in the uterus and not detectable in plasma.
Neg (no) Positive_regulation (increase) of OT in uterus
1) Confidence 0.43 Published 1995 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 8714023 Disease Relevance 0.15 Pain Relevance 0.23
Naloxone infusion was associated with a significant rise in OT from 1.3 +/- 0.1 pmol/l to 4.3 +/- 2.4 pmol/l 5 min after smoking (P less than 0.05).
Positive_regulation (rise) of OT associated with nicotine addiction and narcan
2) Confidence 0.40 Published 1988 Journal Clin. Endocrinol. (Oxf) Section Abstract Doc Link 3214943 Disease Relevance 0.45 Pain Relevance 0.64
Our experimental design increased OT in one-half of the participants with the expectation that DM1s would have a more acute understanding of how DM2s would react to an offer in the UG.
Positive_regulation (increased) of OT
3) Confidence 0.32 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2040517 Disease Relevance 0 Pain Relevance 0.08
By increasing OT the ability to empathize with others, and the motivation to be generous with them, are enhanced.
Positive_regulation (increasing) of OT
4) Confidence 0.23 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2040517 Disease Relevance 0.24 Pain Relevance 0.06
For comparison, a related study of interpersonal trust showed only a 17% increase in DM1 monetary transfers to a stranger in the “trust game” for those given 24 IU intranasal OT compared to those given a placebo [37].
Positive_regulation (increase) of OT
5) Confidence 0.23 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2040517 Disease Relevance 0 Pain Relevance 0.08
Although we artificially raised OT levels in this study to establish a causal mechanism producing generosity, OT can be enhanced nonpharmacologically in a variety of ways, including touching, safe environments, and receiving a signal of trust from another person [31], [34].
Positive_regulation (enhanced) of OT
6) Confidence 0.23 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2040517 Disease Relevance 0.24 Pain Relevance 0.09
We did not find evidence that those given OT were more emotionally labile (using the Affective Intensity Measure [57], p?
Positive_regulation (given) of OT
7) Confidence 0.23 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2040517 Disease Relevance 0.18 Pain Relevance 0.11
But we were surprised by the 80% increase in generosity OT induced in a setting that precluded face-to-face interactions.
Positive_regulation (increase) of OT in face
8) Confidence 0.21 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2040517 Disease Relevance 0 Pain Relevance 0.08
But we were surprised by the 80% increase in generosity OT induced in a setting that precluded face-to-face interactions.
Positive_regulation (induced) of OT in face
9) Confidence 0.21 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2040517 Disease Relevance 0 Pain Relevance 0.08
Barusiban suppressed OT-induced PTL-like uterine contractions with immediate onset of action and high efficacy.
Positive_regulation (induced) of OT in uterine associated with onset of action and dismenorea
10) Confidence 0.21 Published 2007 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC1892056 Disease Relevance 0.50 Pain Relevance 0.50
The elevation of plasma AVP and OT concentrations is further support for the central neuron activation.
Positive_regulation (elevation) of OT in plasma
11) Confidence 0.15 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2570685 Disease Relevance 0 Pain Relevance 0
Naloxone increases the angiotensin II stimulated rise of arginine vasopressin and oxytocin secretion in man.
Positive_regulation (increases) of oxytocin associated with narcan
12) Confidence 0.15 Published 1991 Journal Neuroendocrinology Section Title Doc Link 2041583 Disease Relevance 0 Pain Relevance 0.50
The i.c.v. carbachol significantly increased fetal plasma AVP and OT levels (AVP: F28,6 = 43.23; OT: F28,6 = 35.40, respectively, both P < 0.01, the baseline period vs the period after i.c.v. injection) (Figure 1 and 2).
Positive_regulation (increased) of OT in plasma
13) Confidence 0.13 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2570685 Disease Relevance 0 Pain Relevance 0
Therefore, a sharp increase of OT in the fetal body could be viewed as a critical signal for giving birth, and this hormone contributes partially to initiation of labor.
Positive_regulation (increase) of OT in body
14) Confidence 0.13 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2570685 Disease Relevance 0.15 Pain Relevance 0.03
In light of this, one important significance of the increased OT by the central cholinergic signal in the present study is linked to clinical problem-premature birth.
Positive_regulation (increased) of OT associated with premature birth
15) Confidence 0.13 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2570685 Disease Relevance 0.33 Pain Relevance 0.03
A more likely explanation for the elevation of the fetal plasma AVP and OT is the facilitation by central cholinergic stimuli per se.
Positive_regulation (elevation) of OT in plasma
16) Confidence 0.13 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2570685 Disease Relevance 0.13 Pain Relevance 0.04
Notably, the increased fetal plasma OT by i.c.v. carbachol is less than the increased of AVP compared to the baseline, which is quite different from adults in the same neuropeptide responses [13].
Positive_regulation (increased) of OT in plasma associated with neuropeptide
17) Confidence 0.13 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2570685 Disease Relevance 0 Pain Relevance 0.05
If fetal central cholinergic mechanism is over activated by any factor at the wrong time (before term), it is very likely to induce premature labor due to a significant increase of fetal plasma OT levels.
Positive_regulation (increase) of OT in plasma associated with pre-term labor
18) Confidence 0.13 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2570685 Disease Relevance 0.43 Pain Relevance 0.04
Similar to AVP, the lack of change of the maternal plasma OT suggests that the increased fetal plasma OT is released from its own nerurohypophysis in response to central carbachol and fetal OT seems not pass the placental barrier to the maternal side.
Positive_regulation (increased) of OT in plasma
19) Confidence 0.13 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2570685 Disease Relevance 0 Pain Relevance 0.04
The increase of OT lasted for more than 90 mins.
Positive_regulation (increase) of OT
20) Confidence 0.13 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2570685 Disease Relevance 0 Pain Relevance 0.03

General Comments

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