INT193015

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Context Info
Confidence 0.32
First Reported 2006
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 6
Total Number 12
Disease Relevance 8.77
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (EPAS1) signal transduction (EPAS1) mitochondrion organization (EPAS1)
nucleus (EPAS1) DNA binding (EPAS1) transcription factor binding (EPAS1)
Anatomy Link Frequency
tendon 8
tears 2
MCF-7 2
EPAS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
methotrexate 9 91.28 High High
Potency 3 66.88 Quite High
Osteoarthritis 21 60.08 Quite High
imagery 27 52.08 Quite High
rheumatoid arthritis 10 44.00 Quite Low
vincristine 3 21.32 Low Low
Inflammation 18 5.00 Very Low Very Low Very Low
alcohol 14 5.00 Very Low Very Low Very Low
Pain 11 5.00 Very Low Very Low Very Low
cytokine 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Tendinopathy 14 100.00 Very High Very High Very High
Hypoxia 192 99.98 Very High Very High Very High
Rupture 14 99.28 Very High Very High Very High
Cancer 375 99.24 Very High Very High Very High
Muscular Atrophy 140 96.44 Very High Very High Very High
Solid Tumor 9 95.72 Very High Very High Very High
Toxicity 7 95.60 Very High Very High Very High
Rotator Cuff Tears 140 94.84 High High
Erythrocytosis 92 94.32 High High
Necrosis 6 94.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As a result, the expression of certain HIF target proteins is increased even when oxygen levels are normal.


Positive_regulation (increased) of Gene_expression (expression) of HIF
1) Confidence 0.32 Published 2006 Journal PLoS Medicine Section Abstract Doc Link PMC1479389 Disease Relevance 0.88 Pain Relevance 0
In our findings, HIF expression significantly increases with rising Patte grade.
Positive_regulation (increases) of Gene_expression (expression) of HIF
2) Confidence 0.17 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2958987 Disease Relevance 0.79 Pain Relevance 0
Lewis et al. described increased neovascularity in patients with rotator cuff tendinopathy; increased HIF and VEGF expression in the diseased rotator cuff, but not in tendon retraction [12].
Positive_regulation (increased) of Gene_expression (expression) of HIF in tendon associated with tendinopathy
3) Confidence 0.17 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2958987 Disease Relevance 0.73 Pain Relevance 0
Cyclic loading is as important inducer of HIF expression.
Positive_regulation (inducer) of Gene_expression (expression) of HIF
4) Confidence 0.17 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2958987 Disease Relevance 0.54 Pain Relevance 0
If hypoxia underlies HIF expression, this contradicts Matthews's results describing the poorest blood supply in massive tears [15].
Positive_regulation (underlies) of Gene_expression (expression) of HIF in tears associated with hypoxia
5) Confidence 0.17 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2958987 Disease Relevance 0.65 Pain Relevance 0
Therefore, it remains unclear whether hypoxia or cyclic tendon loading is the underlying reason for HIF and VEGF expression.
Spec (whether) Positive_regulation (reason) of Gene_expression (expression) of HIF in tendon associated with hypoxia
6) Confidence 0.13 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2958987 Disease Relevance 0.89 Pain Relevance 0.06
We assume that complete tendon rupture reduces mechanical cyclic loading, resulting in reduced HIF expression.
Positive_regulation (resulting) of Gene_expression (expression) of HIF in tendon associated with rupture
7) Confidence 0.12 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2958987 Disease Relevance 0.61 Pain Relevance 0
HIF and VEGF expression, and vessel density significantly increased with extent of tendon retraction (p < 0.05).
Positive_regulation (increased) of Gene_expression (expression) of HIF in tendon
8) Confidence 0.12 Published 2010 Journal BMC Musculoskelet Disord Section Abstract Doc Link PMC2958987 Disease Relevance 0.78 Pain Relevance 0
expression was found to be related to tumour vascularity, suggesting that hypoxia induces TAM clustering and over-expression of TAM HIF-2?
Positive_regulation (induces) of Gene_expression (expression) of HIF associated with hypoxia and cancer
9) Confidence 0.11 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2246178 Disease Relevance 1.24 Pain Relevance 0
The HIF response is mediated through the transcription factor dimer inducible HIF-1?
Positive_regulation (mediated) of Gene_expression (response) of HIF
10) Confidence 0.07 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2246178 Disease Relevance 0.83 Pain Relevance 0
Oestrogen is known to enhance VEGF expression (which may be partly HIF mediated [124]), and tamoxifen inhibits VEGF and FGF stimulated angiogenesis, resulting in a decrease in microvessel density and an increase in necrosis in MCF-7 xenografts [125-130].
Positive_regulation (enhance) of Gene_expression (expression) of HIF in MCF-7 associated with necrosis
11) Confidence 0.07 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2246178 Disease Relevance 0.35 Pain Relevance 0.12
that HIF overexpression is involved in HLRCC tumorigenesis [42, 63].
Positive_regulation (overexpression) of Gene_expression (overexpression) of HIF
12) Confidence 0.03 Published 2008 Journal Advances in Urology Section Body Doc Link PMC2581790 Disease Relevance 0.48 Pain Relevance 0.03

General Comments

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