INT193016

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Context Info
Confidence 0.15
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 7.38
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (EPAS1) signal transduction (EPAS1) mitochondrion organization (EPAS1)
nucleus (EPAS1) DNA binding (EPAS1) transcription factor binding (EPAS1)
Anatomy Link Frequency
cardiovascular systems 1
respiratory 1
EPAS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 2 75.76 Quite High
Pain 5 34.72 Quite Low
Central nervous system 2 20.72 Low Low
imagery 18 5.00 Very Low Very Low Very Low
cytokine 7 5.00 Very Low Very Low Very Low
Osteoarthritis 6 5.00 Very Low Very Low Very Low
cva 6 5.00 Very Low Very Low Very Low
alcohol 4 5.00 Very Low Very Low Very Low
aspirin 4 5.00 Very Low Very Low Very Low
headache 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 192 100.00 Very High Very High Very High
Renal Cancer 134 100.00 Very High Very High Very High
Syndrome 159 98.38 Very High Very High Very High
Pheochromocytoma 50 98.32 Very High Very High Very High
Cancer 165 97.92 Very High Very High Very High
Erythrocytosis 184 96.42 Very High Very High Very High
Tendinopathy 4 94.80 High High
Targeted Disruption 4 90.24 High High
Rotator Cuff Tears 40 86.92 High High
Tuberous Sclerosis 1 86.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since HIF induction was initially described in conditions of decreased oxygen partial pressure, the majority of studies on HIF regulation have addressed hypoxic conditions [34].
Regulation (regulation) of HIF associated with hypoxia
1) Confidence 0.15 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2958987 Disease Relevance 0.64 Pain Relevance 0.03
More generally, the phenotype associated with Chuvash polycythaemia demonstrates that VHL plays a major role in the underlying calibration and homeostasis of the respiratory and cardiovascular systems, most likely through its central role in the regulation of HIF.


Regulation (regulation) of HIF in cardiovascular systems associated with erythrocytosis
2) Confidence 0.12 Published 2006 Journal PLoS Medicine Section Abstract Doc Link PMC1479389 Disease Relevance 0.81 Pain Relevance 0
HIF, which is induced by cell hypoxia, is one of the most important regulators of VEGF gene expression [28].
Regulation (regulators) of HIF associated with hypoxia
3) Confidence 0.11 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2958987 Disease Relevance 1.14 Pain Relevance 0.04
expression depends on mTORC1 and mTORC2 expression whilst HIF-2?
Regulation (depends) of HIF
4) Confidence 0.08 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004583 Disease Relevance 0.80 Pain Relevance 0
More generally, the phenotype associated with Chuvash polycythaemia demonstrates that VHL plays a major role in the underlying calibration and homeostasis of the respiratory and cardiovascular systems, most likely through its central role in the regulation of HIF.


Regulation (regulation) of HIF in respiratory associated with erythrocytosis
5) Confidence 0.04 Published 2006 Journal PLoS Medicine Section Abstract Doc Link PMC1479389 Disease Relevance 0.81 Pain Relevance 0
whereas type 2A mutations result in an incomplete defect in HIF regulation [16].
Regulation (regulation) of HIF
6) Confidence 0.04 Published 2008 Journal Advances in Urology Section Body Doc Link PMC2581790 Disease Relevance 0.63 Pain Relevance 0
regulates HIF but is defective in fibronectin assembly, indicating a possible
Regulation (regulates) of HIF
7) Confidence 0.04 Published 2008 Journal Advances in Urology Section Body Doc Link PMC2581790 Disease Relevance 0.54 Pain Relevance 0
From in vivo experiments in mice, Hoffmann et al., has described a group of VHL type 2C mutants which all retained the ability to interact with HIF and to down regulate HIF target genes when reintroduced into pVHL defective tumour cells.
Regulation (regulate) of HIF associated with cancer and syndrome
8) Confidence 0.01 Published 2007 Journal World J Surg Oncol Section Body Doc Link PMC2169240 Disease Relevance 1.45 Pain Relevance 0
Inappropriate activation of the hypoxia response pathway, is the major mechanism of VEGF transcriptional regulation in renal cell carcinoma.2 The HIF?
Regulation (regulation) of HIF associated with hypoxia and renal cancer
9) Confidence 0.00 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004565 Disease Relevance 0.56 Pain Relevance 0

General Comments

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