INT193019

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Context Info
Confidence 0.39
First Reported 2006
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 6
Total Number 9
Disease Relevance 4.70
Pain Relevance 0.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (SMUG1) hydrolase activity, acting on glycosyl bonds (SMUG1) nucleolus (SMUG1)
nucleus (SMUG1) DNA binding (SMUG1)
Anatomy Link Frequency
left uterine horn 4
uterine horn 4
macrophages 2
rim 2
parenchyma 2
SMUG1 (Homo sapiens)
Pain Link Frequency Relevance Heat
imagery 137 93.44 High High
fibrosis 5 92.52 High High
positron emission tomography 145 91.04 High High
Bile 1 88.52 High High
Inflammation 31 72.00 Quite High
pruritus 1 41.76 Quite Low
abdominal pain 1 41.24 Quite Low
palliative 2 36.12 Quite Low
medulla 18 5.00 Very Low Very Low Very Low
corticosteroid 14 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Atherosclerosis 33 99.84 Very High Very High Very High
Metastasis 103 99.72 Very High Very High Very High
Lymphatic System Cancer 9 99.68 Very High Very High Very High
Disease 46 99.08 Very High Very High Very High
Fibromyalgia 84 98.50 Very High Very High Very High
Bronchiolitis Obliterans Organizing Pneumonia 109 98.28 Very High Very High Very High
Pleural Effusion 5 96.24 Very High Very High Very High
Fibrosis 6 92.52 High High
Hyperinsulinism 4 88.92 High High
Nephrotoxicity 21 87.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is very interesting to mention that in the case of a low-grade lymphoma, an unexpected increase in FDG accumulation in any or all known parts of the disease during follow-up suggests transformation to a higher grade lymphoma [74-77].
Positive_regulation (increase) of Positive_regulation (accumulation) of FDG associated with lymphatic system cancer and disease
1) Confidence 0.39 Published 2010 Journal The Yale Journal of Biology and Medicine Section Body Doc Link PMC2892773 Disease Relevance 0.91 Pain Relevance 0.13
This is consistent with the finding in our studies, suggesting that macrophages are responsible for the accumulation of FDG in atherosclerotic lesions.
Positive_regulation (responsible) of Positive_regulation (accumulation) of FDG in macrophages associated with atherosclerosis
2) Confidence 0.26 Published 2006 Journal BMC Nucl Med Section Body Doc Link PMC1479805 Disease Relevance 0.77 Pain Relevance 0.17
Two of these metastases showed a rim-enhancement, without any central enhancement on CT but marked central FDG-uptake on PET scans (Fig. 4).
Positive_regulation (enhancement) of Neg (without) Positive_regulation (enhancement) of FDG in rim associated with metastasis
3) Confidence 0.19 Published 2010 Journal Pediatr Radiol Section Body Doc Link PMC2895865 Disease Relevance 0.75 Pain Relevance 0.08
A recent study has shown that patients with an enhanced 18F- FDG accumulation reflect the degree of disease activity in BOOP.[128]

Diagnosing BOOP

Positive_regulation (enhanced) of Positive_regulation (accumulation) of FDG associated with bronchiolitis obliterans organizing pneumonia and disease
4) Confidence 0.17 Published 2008 Journal Annals of Thoracic Medicine Section Body Doc Link PMC2700454 Disease Relevance 1.30 Pain Relevance 0.08
Importantly, the left uterine horn accumulated more FDG than the right uterine horn (Fig. 3c), primarily due to enhanced FDG accumulation during the catheter infusion phase, consistent with greater first pass exposure to glucose tracer.


Positive_regulation (enhanced) of Positive_regulation (accumulation) of FDG in left uterine horn
5) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2917372 Disease Relevance 0 Pain Relevance 0.14
Importantly, the left uterine horn accumulated more FDG than the right uterine horn (Fig. 3c), primarily due to enhanced FDG accumulation during the catheter infusion phase, consistent with greater first pass exposure to glucose tracer.


Positive_regulation (accumulated) of Positive_regulation (accumulation) of FDG in left uterine horn
6) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2917372 Disease Relevance 0 Pain Relevance 0.21
By selecting left-sided-FMS-flow animals only under hyperinsulinemic conditions, there was a 3.7-fold increased accumulation of FDG in the left- versus right- uterine horn fetuses (p<10-4, n?
Positive_regulation (increased) of Positive_regulation (accumulation) of FDG in uterine horn associated with fibromyalgia
7) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2917372 Disease Relevance 0.56 Pain Relevance 0
We thus tested the hypothesis that surgical approach “B”, in which we additionally tied off these two arterial trunks, would result in a more differential FDG accumulation between the two uterine horns.
Positive_regulation (result) of Positive_regulation (accumulation) of FDG in uterine horns
8) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2917372 Disease Relevance 0.06 Pain Relevance 0
We assessed renal 18F-fluoride clearance in a subgroup of animals to exclude decreased renal function as a potential cause for increased FDG-uptake into the renal parenchyma.
Positive_regulation (cause) of Positive_regulation (increased) of FDG in parenchyma
9) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2669171 Disease Relevance 0.34 Pain Relevance 0.03

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