INT193031

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Context Info
Confidence 0.00
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.12
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (ROCK1) signal transduction (ROCK1) Golgi apparatus (ROCK1)
cytoskeleton (ROCK1) plasma membrane (CHRM2) cytoplasm (ROCK1)
Anatomy Link Frequency
smooth muscle 1
CHRM2 (Homo sapiens)
ROCK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 27 96.84 Very High Very High Very High
cytokine 4 63.80 Quite High
Inflammation 31 63.40 Quite High
Inflammatory mediators 4 5.00 Very Low Very Low Very Low
antagonist 4 5.00 Very Low Very Low Very Low
bradykinin 3 5.00 Very Low Very Low Very Low
Neurotransmitter 2 5.00 Very Low Very Low Very Low
c fibre 2 5.00 Very Low Very Low Very Low
COX2 1 5.00 Very Low Very Low Very Low
tetrodotoxin 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 36 63.40 Quite High
Targeted Disruption 2 53.32 Quite High
Asthma 39 50.00 Quite Low
Disease 13 24.24 Low Low
Pulmonary Disease 51 20.60 Low Low
Occupational Lung Diseases 3 20.24 Low Low
Congenital Anomalies 1 16.40 Low Low
Airway Remodeling 17 5.00 Very Low Very Low Very Low
Hypertrophy 6 5.00 Very Low Very Low Very Low
Hyperplasia 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The RhoA/Rho-kinase cascade, a key regulatory pathway of Ca2+ sensitivity in airway smooth muscle, can be activated by both muscarinic M2 and muscarinic M3 receptors [38,39].
muscarinic M2 Positive_regulation (activated) of Rho-kinase in smooth muscle
1) Confidence 0.00 Published 2006 Journal Respir Res Section Body Doc Link PMC1479816 Disease Relevance 0.12 Pain Relevance 0.24

General Comments

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