INT193037
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
This trend continued until the end of the time-course, with a higher frequency of live cells found in the M2-transduced population versus the M2.Stop retrovirus control (Figure 2B). | |||||||||||||||
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At day 2 post-transduction, the M2-transduced cells have equal frequencies of live cells as the control M2.Stop retrovirus transduced cells (Figure 2B). | |||||||||||||||
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To examine the roles of M2, M4 and D2 receptors in male-female interactions, we measured USVs of M2 and M4 KO mice. | |||||||||||||||
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Furthermore, given the effects of M2, M4, M5 muscarinic receptors and the D2 dopamine receptor in dopamine release [23][25], [66], and their varied and wide distribution in the brain [28], [29], we postulate that, these receptors are more likely to contribute to the regulation of emotion and motivation. | |||||||||||||||
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By studying knockout mice, we further found that: 1) USVs were lost in about 75% of M2 KO mice, associated with a loss of sexual interaction. 2) In M5 KO mice, frequency-modulated USVs from male mice were reduced by almost 80%. 3) USVs were not altered reliably in M4 KO mice. 4) M2, M5 and D2 receptors played a role in either duration or peak or bandwidth of USVs. | |||||||||||||||
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While we continued to evaluate the protective efficacy of NP and M2 in the mouse model, we extended our investigation into the ferret model in this study. | |||||||||||||||
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Significant anti-M2 humoral responses were detected in animals immunized with NP+M2 post-rAd boost (p? | |||||||||||||||
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M2 is responsible for protein translocation, and is expressed at a high density in the plasma membrane of infected cells in tetramer forms. | |||||||||||||||
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The corresponding Emax values in wild-type and M2 receptor knockout mice were approximately the same, but that in the M3 receptor knockout mouse was only 36% of wild type. | |||||||||||||||
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Ferrets were immunized with HA alone, NP alone, M2 alone, NP+M2, HA+NP+M2, and control using gene-based vaccines delivered in DNA/rAd5 vectors. | |||||||||||||||
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Here, we investigate the relative efficacy of NP and M2 compared to HA in protecting against HPAI H5N1 virus. | |||||||||||||||
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Distinct mechanisms underlie the M2 autoreceptor dysfunction. | |||||||||||||||
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Cholinergic neurotransmission in the parasympathetic ganglia is regulated by nicotinic receptors in conjunction with muscarinic M1 receptors, whereas ganglionic release of acetylcholine from preganglionic nerves is under regulation of M2 autoreceptors [61,62] (Figure 2). | |||||||||||||||
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However, we find that the protective efficacy of NP and M2 diminishes as the virulence and dose of the challenge virus are increased. | |||||||||||||||
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General Comments
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