INT193042

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Context Info
Confidence 0.28
First Reported 2006
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 15
Total Number 15
Disease Relevance 3.93
Pain Relevance 0.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Chrm2) plasma membrane (Chrm2) signal transducer activity (Chrm2)
Anatomy Link Frequency
plasma cell 8
B cells 8
lymphocytes 2
Chrm2 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 237 99.76 Very High Very High Very High
Inflammation 97 97.92 Very High Very High Very High
antagonist 4 97.12 Very High Very High Very High
Inflammatory mediators 7 45.92 Quite Low
bradykinin 3 38.08 Quite Low
c fibre 2 12.32 Low Low
agonist 35 5.00 Very Low Very Low Very Low
anesthesia 16 5.00 Very Low Very Low Very Low
chemokine 13 5.00 Very Low Very Low Very Low
Potency 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pulmonary Disease 51 99.96 Very High Very High Very High
Asthma 39 99.78 Very High Very High Very High
Lymphatic System Cancer 65 99.36 Very High Very High Very High
Viral Infection 17 99.02 Very High Very High Very High
INFLAMMATION 112 97.92 Very High Very High Very High
Retroviridae Infections 10 91.72 High High
Apoptosis 32 88.16 High High
Cancer 85 85.00 Quite High
Sprains And Strains 41 81.20 Quite High
Infection 523 80.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Among the genes that were upregulated upon expression of M2 in the BCL-1 B lymphoma cell line was the cellular transcription factor IRF4 (Fig. 6C, and unpublished data), which has been shown to be required for both isotype switching as well as plasma cell differentiation [2].
Positive_regulation (upregulated) of Gene_expression (expression) of M2 in plasma cell associated with lymphatic system cancer
1) Confidence 0.28 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2777334 Disease Relevance 0.10 Pain Relevance 0
Together, these data provide strong evidence that M2 expression leads to B cell activation and differentiation similar to a functional activated, pre-plasma memory B cell phenotype, namely CD19+, sIgG+, sIgD?
Positive_regulation (leads) of Gene_expression (expression) of M2 in B cell
2) Confidence 0.24 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2270344 Disease Relevance 0.06 Pain Relevance 0
M2 co-immunoprecipitates with Vav1 in S11 B cells, a MHV68 latently infected cell line, and M2 and Vav1 overexpression in A20 B cells leads to Vav1 phosphorylation, trimerization with Fyn, and downstream activation of Rac1 [27].
Positive_regulation (overexpression) of Gene_expression (overexpression) of M2 in B cells
3) Confidence 0.22 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2270344 Disease Relevance 0.26 Pain Relevance 0
These data demonstrate that M2 expression in primary murine B cells leads to enhanced secretion of several cytokines, most notably IL-10.
Positive_regulation (leads) of Gene_expression (expression) of M2 in B cells associated with cytokine
4) Confidence 0.21 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2270344 Disease Relevance 0 Pain Relevance 0.10
Similarly, the M2 and M2.Stop transduced populations both upregulated CD138, although the presence of M2 did not lead to the high levels of CD138 indicative of plasma cell differentiation.
Positive_regulation (populations) of Gene_expression (transduced) of M2 in plasma cell
5) Confidence 0.21 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2270344 Disease Relevance 0.15 Pain Relevance 0
Strikingly, M2-transduced cells expressed higher levels of CD25 as compared to cells transduced with the control retrovirus, although the MFI of CD25 was similar between the two populations (Figure 3A).
Positive_regulation (levels) of Gene_expression (expressed) of M2
6) Confidence 0.21 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2270344 Disease Relevance 0.16 Pain Relevance 0
Similarly, the M2 and M2.Stop transduced populations both upregulated CD138, although the presence of M2 did not lead to the high levels of CD138 indicative of plasma cell differentiation.
Positive_regulation (populations) of Gene_expression (transduced) of M2 in plasma cell
7) Confidence 0.21 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2270344 Disease Relevance 0.15 Pain Relevance 0
M2 protein expression leads to secretion of IL-10
Positive_regulation (leads) of Gene_expression (expression) of M2
8) Confidence 0.21 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2270344 Disease Relevance 0 Pain Relevance 0.12
Similarly, the M2 and M2.Stop transduced populations both upregulated CD138, although the presence of M2 did not lead to the high levels of CD138 indicative of plasma cell differentiation.
Neg (not) Positive_regulation (lead) of Gene_expression (presence) of M2 in plasma cell
9) Confidence 0.21 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2270344 Disease Relevance 0.15 Pain Relevance 0
However, transfection with the M2 expression vector lead to a substantial increase in the levels of IL-10 secretion (Figure 4F).
Positive_regulation (transfection) of Gene_expression (transfection) of M2
10) Confidence 0.20 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2270344 Disease Relevance 0.07 Pain Relevance 0.07
However, transfection with the M2 expression vector lead to a substantial increase in the levels of IL-10 secretion (Figure 4F).
Positive_regulation (transfection) of Gene_expression (expression) of M2
11) Confidence 0.20 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2270344 Disease Relevance 0.07 Pain Relevance 0.07
Notably, M2 expression (in the absence of other viral proteins) could only weakly upregulated (<3-fold) gene 50 promoter activity (data not shown), indicating that the role of M2 in virus reactivation from the latently infected M12 B cell lines is unlikely to be via direct targeting/regulation of gene 50 transcription.
Positive_regulation (upregulated) of Gene_expression (expression) of M2 in B cell
12) Confidence 0.19 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2777334 Disease Relevance 0.14 Pain Relevance 0
However, M2 antibodies were only stimulated when M2 was in combination with NP, suggesting possible immune synergy of the two gene products.
Positive_regulation (stimulated) of Gene_expression (antibodies) of M2
13) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2843722 Disease Relevance 0.63 Pain Relevance 0
were collectively termed ¬ďalternatively activated¬Ē or M2: Th2 cytokines, such
Positive_regulation (activated) of Gene_expression (termed) of M2 associated with cytokine
14) Confidence 0.05 Published 2008 Journal PPAR Research Section Body Doc Link PMC2443396 Disease Relevance 1.03 Pain Relevance 0.39
Viral infections, which may play a role in both asthma and COPD, induce M2 dysfunction through neuraminidases that cleave portions of the M2 receptor, and through as yet incompletely characterized mechanisms involving macrophages, CD8+ lymphocytes, and possibly IFN-?
Positive_regulation (induce) of Gene_expression (dysfunction) of M2 in lymphocytes associated with asthma, pulmonary disease and viral infection
15) Confidence 0.03 Published 2006 Journal Respir Res Section Body Doc Link PMC1479816 Disease Relevance 0.97 Pain Relevance 0.10

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