INT193055

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Context Info
Confidence 0.03
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.19
Pain Relevance 0.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (CHRM2) signal transducer activity (CHRM2)
Anatomy Link Frequency
neuronal 1
smooth muscle 1
bladder 1
CHRM2 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 73 97.78 Very High Very High Very High
antagonist 19 76.64 Quite High
Eae 6 65.76 Quite High
Inflammation 53 62.80 Quite High
cva 1 22.96 Low Low
Neurotransmitter 2 22.36 Low Low
cytokine 12 5.84 Low Low
Inflammatory mediators 4 5.00 Very Low Very Low Very Low
c fibre 4 5.00 Very Low Very Low Very Low
Potency 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Overactive Bladder 73 98.44 Very High Very High Very High
Asthma 81 91.60 High High
Pulmonary Disease 51 87.08 High High
Apoptosis 22 85.04 High High
Eosinophilia 1 84.56 Quite High
Targeted Disruption 2 64.96 Quite High
INFLAMMATION 58 62.80 Quite High
Airway Remodeling 17 60.64 Quite High
Bacterial Respiratory Disease 6 46.72 Quite Low
Viral Infection 8 39.20 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Airway smooth muscle expresses abundant muscarinic M2 and M3 receptors, roughly in a 4:1 ratio [8].
Positive_regulation (abundant) of muscarinic M2 in smooth muscle
1) Confidence 0.03 Published 2006 Journal Respir Res Section Body Doc Link PMC1479816 Disease Relevance 0.63 Pain Relevance 0.10
3-AR agonists, at the beginning of the voiding phase, the relaxation of bladder smooth muscle may be canceled by muscarinic M2-receptor activation, but muscarinic M3-receptor-mediated bladder contraction can remain intact, suggesting in turn little risk of ?
Positive_regulation (activation) of M2-receptor in bladder associated with agonist and overactive bladder
2) Confidence 0.03 Published 2010 Journal Korean Journal of Urology Section Body Doc Link PMC3016425 Disease Relevance 0.78 Pain Relevance 0.31
In animals exposed to low concentrations of organophosphorus pesticides, neuronal M2 muscarinic receptor function is lost, increasing release of acetylcholine and potentiating bronchoconstriction (Fryer et al. 2004; Lein and Fryer 2005).
Positive_regulation (increasing) of M2 muscarinic receptor in neuronal
3) Confidence 0.02 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2265045 Disease Relevance 0.70 Pain Relevance 0
The TM receptor CD74 antigen was also upregulated after 6 h exposure.
Positive_regulation (upregulated) of TM receptor
4) Confidence 0.01 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2519092 Disease Relevance 0.09 Pain Relevance 0
The upregulated HLA-A TM receptor is involved in immune responses and modulates, upon interaction with natural killer (NK) cells, cytotoxicity.
Positive_regulation (upregulated) of TM receptor
5) Confidence 0.00 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2519092 Disease Relevance 0 Pain Relevance 0

General Comments

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