INT193058

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Context Info
Confidence 0.28
First Reported 2006
Last Reported 2009
Negated 5
Speculated 0
Reported most in Body
Documents 2
Total Number 6
Disease Relevance 1.01
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (CHRM2) signal transducer activity (CHRM2)
Anatomy Link Frequency
choroid 6
macrophages 2
retina 1
sclera 1
ciliary body 1
CHRM2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 31 62.36 Quite High
cytokine 4 60.00 Quite High
agonist 27 38.20 Quite Low
chemokine 1 13.60 Low Low
antagonist 89 5.00 Very Low Very Low Very Low
Dopamine 10 5.00 Very Low Very Low Very Low
Neurotransmitter 7 5.00 Very Low Very Low Very Low
ketamine 5 5.00 Very Low Very Low Very Low
anesthesia 5 5.00 Very Low Very Low Very Low
depression 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pulmonary Disease 51 99.40 Very High Very High Very High
Nicotine Addiction 1 84.12 Quite High
Myopia 285 64.40 Quite High
Asthma 44 62.76 Quite High
INFLAMMATION 36 62.36 Quite High
Disease 13 10.24 Low Low
Airway Remodeling 17 5.00 Very Low Very Low Very Low
Ganglion Cysts 10 5.00 Very Low Very Low Very Low
Hypertrophy 6 5.00 Very Low Very Low Very Low
Ocular Toxicity (including Many Sub-types) 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The iris/ciliary body, retina, choroid, and sclera expressed all five muscarinic receptor subtypes while CHRM2 expression was not detected in the cornea.
Neg (not) Negative_regulation (detected) of Gene_expression (expression) of CHRM2 in choroid
1) Confidence 0.28 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2649308 Disease Relevance 0.06 Pain Relevance 0
The iris/ciliary body, retina, choroid, and sclera expressed all five muscarinic receptor subtypes while CHRM2 expression was not detected in the cornea.
Neg (not) Negative_regulation (detected) of in iris Gene_expression (expression) of CHRM2 in choroid
2) Confidence 0.09 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2649308 Disease Relevance 0.06 Pain Relevance 0
The iris/ciliary body, retina, choroid, and sclera expressed all five muscarinic receptor subtypes while CHRM2 expression was not detected in the cornea.
Neg (not) Negative_regulation (detected) of in retina Gene_expression (expression) of CHRM2 in choroid
3) Confidence 0.09 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2649308 Disease Relevance 0.06 Pain Relevance 0
The iris/ciliary body, retina, choroid, and sclera expressed all five muscarinic receptor subtypes while CHRM2 expression was not detected in the cornea.
Neg (not) Negative_regulation (detected) of in sclera Gene_expression (expression) of CHRM2 in choroid
4) Confidence 0.09 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2649308 Disease Relevance 0.06 Pain Relevance 0
The iris/ciliary body, retina, choroid, and sclera expressed all five muscarinic receptor subtypes while CHRM2 expression was not detected in the cornea.
Neg (not) Negative_regulation (detected) of in ciliary body Gene_expression (expression) of CHRM2 in choroid
5) Confidence 0.09 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2649308 Disease Relevance 0.06 Pain Relevance 0
Importantly, the expression of muscarinic M3 receptors on macrophages is significantly increased in COPD patients, whereas muscarinic M2 receptor expression is decreased.
Negative_regulation (decreased) of Gene_expression (expression) of M2 receptor in macrophages associated with pulmonary disease
6) Confidence 0.02 Published 2006 Journal Respir Res Section Body Doc Link PMC1479816 Disease Relevance 0.68 Pain Relevance 0.06

General Comments

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