INT193070

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Context Info
Confidence 0.17
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.03
Pain Relevance 0.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CHAT) mitochondrion (CHAT) nucleus (CHAT)
transferase activity, transferring acyl groups (CHAT) cytoplasm (CHAT)
Anatomy Link Frequency
vesicles 2
CHAT (Homo sapiens)
Pain Link Frequency Relevance Heat
Dopamine 1 97.68 Very High Very High Very High
Serotonin 5 97.48 Very High Very High Very High
Neurotransmitter 6 97.10 Very High Very High Very High
Inflammation 62 96.76 Very High Very High Very High
Central nervous system 1 83.00 Quite High
methadone 135 72.56 Quite High
Enkephalin 3 64.64 Quite High
Nerve growth factor 1 63.44 Quite High
agonist 76 63.04 Quite High
cytokine 8 57.40 Quite High
Disease Link Frequency Relevance Heat
Disease 26 97.40 Very High Very High Very High
INFLAMMATION 72 96.76 Very High Very High Very High
Pulmonary Disease 102 79.84 Quite High
Hypersensitivity 8 66.16 Quite High
Asthma 78 50.00 Quite Low
Opiate Addiction 27 46.80 Quite Low
Newborn Drug Withdrawal Syndrome 37 35.68 Quite Low
Viral Infection 6 25.84 Quite Low
Occupational Lung Diseases 6 15.68 Low Low
Airway Remodeling 34 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Neuronal acetylcholine is synthesized by the enzyme choline acetyl transferase (ChAT), stored in vesicles, and released upon membrane depolarization.
Localization (released) of choline acetyl transferase in vesicles
1) Confidence 0.17 Published 2006 Journal Respir Res Section Body Doc Link PMC1479816 Disease Relevance 0.52 Pain Relevance 0.14
Neuronal acetylcholine is synthesized by the enzyme choline acetyl transferase (ChAT), stored in vesicles, and released upon membrane depolarization.
Localization (released) of ChAT in vesicles
2) Confidence 0.17 Published 2006 Journal Respir Res Section Body Doc Link PMC1479816 Disease Relevance 0.51 Pain Relevance 0.14
In particular, there are consistent decreases in protein, DNA, RNA and neurotransmitter content (serotonin, dopamine, norepinephrine) [87, 145, 253, 301, 344], enzymatic protein levels (tyrosine hydroxylase, acetylcholine-esterase, choline acetyltransferase, ornithine decarboxylase) [87, 224, 327, 338, 342, 343], and receptor expression (?
Localization (choline acetyltransferase) of choline acetyltransferase associated with dopamine, neurotransmitter and serotonin
3) Confidence 0.02 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647150 Disease Relevance 0 Pain Relevance 0.59

General Comments

This test has worked.

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