INT193072

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Context Info
Confidence 0.41
First Reported 2006
Last Reported 2009
Negated 6
Speculated 0
Reported most in Body
Documents 2
Total Number 7
Disease Relevance 3.39
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (CHRM2) signal transducer activity (CHRM2)
Anatomy Link Frequency
retina 1
lymphocytes 1
sclera 1
choroid 1
ciliary body 1
CHRM2 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 106 94.84 High High
Inflammation 31 62.88 Quite High
Inflammatory mediators 4 50.96 Quite High
bradykinin 3 43.12 Quite Low
c fibre 2 17.36 Low Low
agonist 27 5.00 Very Low Very Low Very Low
Dopamine 12 5.00 Very Low Very Low Very Low
Neurotransmitter 8 5.00 Very Low Very Low Very Low
ketamine 6 5.00 Very Low Very Low Very Low
anesthesia 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pulmonary Disease 51 98.82 Very High Very High Very High
Asthma 45 98.64 Very High Very High Very High
Viral Infection 3 97.88 Very High Very High Very High
Myopia 342 97.16 Very High Very High Very High
Occupational Lung Diseases 3 74.36 Quite High
Disease 13 66.36 Quite High
Hypersensitivity 4 64.16 Quite High
INFLAMMATION 36 62.88 Quite High
Airway Remodeling 17 5.00 Very Low Very Low Very Low
Ganglion Cysts 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The CHRM2 subtype mRNA was not detected in the current study depite the use of multiple amplification conditions.
Neg (not) Transcription (detected) of CHRM2
1) Confidence 0.41 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2649308 Disease Relevance 0 Pain Relevance 0.04
All five mAChR subtypes were found in the tree shrew iris/ciliary body, retina, choroid, and sclera while CHRM2 mRNA was not detected in the cornea. mAChR subtype mRNA expression was not altered early in myopia development in the retina, choroid, or sclera either before or after significant axial elongation.
Neg (not) Transcription (detected) of CHRM2 in iris associated with myopia
2) Confidence 0.35 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2649308 Disease Relevance 0.50 Pain Relevance 0
All five mAChR subtypes were found in the tree shrew iris/ciliary body, retina, choroid, and sclera while CHRM2 mRNA was not detected in the cornea. mAChR subtype mRNA expression was not altered early in myopia development in the retina, choroid, or sclera either before or after significant axial elongation.
Neg (not) Transcription (detected) of CHRM2 in ciliary body associated with myopia
3) Confidence 0.12 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2649308 Disease Relevance 0.50 Pain Relevance 0
All five mAChR subtypes were found in the tree shrew iris/ciliary body, retina, choroid, and sclera while CHRM2 mRNA was not detected in the cornea. mAChR subtype mRNA expression was not altered early in myopia development in the retina, choroid, or sclera either before or after significant axial elongation.
Neg (not) Transcription (detected) of CHRM2 in retina associated with myopia
4) Confidence 0.12 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2649308 Disease Relevance 0.50 Pain Relevance 0
All five mAChR subtypes were found in the tree shrew iris/ciliary body, retina, choroid, and sclera while CHRM2 mRNA was not detected in the cornea. mAChR subtype mRNA expression was not altered early in myopia development in the retina, choroid, or sclera either before or after significant axial elongation.
Neg (not) Transcription (detected) of CHRM2 in sclera associated with myopia
5) Confidence 0.12 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2649308 Disease Relevance 0.50 Pain Relevance 0
All five mAChR subtypes were found in the tree shrew iris/ciliary body, retina, choroid, and sclera while CHRM2 mRNA was not detected in the cornea. mAChR subtype mRNA expression was not altered early in myopia development in the retina, choroid, or sclera either before or after significant axial elongation.
Neg (not) Transcription (detected) of CHRM2 in choroid associated with myopia
6) Confidence 0.12 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2649308 Disease Relevance 0.50 Pain Relevance 0
Viral infections, which may play a role in both asthma and COPD, induce M2 dysfunction through neuraminidases that cleave portions of the M2 receptor, and through as yet incompletely characterized mechanisms involving macrophages, CD8+ lymphocytes, and possibly IFN-?
Transcription (portions) of M2 receptor in lymphocytes associated with asthma, pulmonary disease and viral infection
7) Confidence 0.04 Published 2006 Journal Respir Res Section Body Doc Link PMC1479816 Disease Relevance 0.91 Pain Relevance 0.10

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