INT193078

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Context Info
Confidence 0.15
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.67
Pain Relevance 0.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (PLAU) extracellular region (PLAU)
Anatomy Mention Frequency
smooth muscle cells 1
PLAU (Bos taurus)
Pain Term Frequency Confidence Heat
Inflammation 31 98.40 Very High Very High Very High
agonist 27 96.62 Very High Very High Very High
COX2 1 93.84 High High
Inflammatory response 1 86.16 High High
cytokine 4 60.20 Quite High
chemokine 1 59.68 Quite High
tetrodotoxin 1 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
Neurotransmitter 2 5.00 Very Low Very Low Very Low
Inflammatory mediators 4 5.00 Very Low Very Low Very Low
Disease Term Frequency Confidence Heat
INFLAMMATION 36 98.40 Very High Very High Very High
Asthma 39 57.92 Quite High
Pulmonary Disease 51 57.04 Quite High
Airway Remodeling 17 49.12 Quite Low
Disease 13 13.12 Low Low
Fibrosis 1 5.00 Very Low Very Low Very Low
Occupational Lung Diseases 3 5.00 Very Low Very Low Very Low
Hyperplasia 4 5.00 Very Low Very Low Very Low
Cough 1 5.00 Very Low Very Low Very Low
Eczema 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Muscarinic receptors on airway smooth muscle cells may play a profound role in regulating airway inflammation: a recent study demonstrates that the muscarinic receptor agonist carbachol increases inflammatory gene transcription in bovine tracheal smooth muscle strips [99]; quantitative RT-PCR analysis demonstrates that carbachol can modulate expression of a number of genes, including IL-8, cyclo-oxygenase (COX) 1 and 2 and urokinase type plasminogen activator (PLAU); and, carbachol markedly augments pro-inflammatory gene expression induced by sinusoidal length oscillation, with synergistic effects on IL-6, IL-8 and COX 2 and to a lesser extent PLAU and CCL-2 [99].
Gene_expression (expression) of PLAU in smooth muscle cells associated with inflammation, agonist and cox2
1) Confidence 0.15 Published 2006 Journal Respir Res Section Body Doc Link PMC1479816 Disease Relevance 0.67 Pain Relevance 0.43

General Comments

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