INT193102

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Context Info
Confidence 0.64
First Reported 2006
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 9
Total Number 11
Disease Relevance 10.62
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Xiap) nucleus (Xiap) intracellular (Xiap)
protein complex (Xiap) ligase activity (Xiap) cytoplasm (Xiap)
Anatomy Link Frequency
nucleus 2
lung 2
Xiap (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 11 86.08 High High
tolerance 1 69.04 Quite High
Inflammation 3 55.52 Quite High
depression 9 5.00 Very Low Very Low Very Low
headache 9 5.00 Very Low Very Low Very Low
COX-2 inhibitor 3 5.00 Very Low Very Low Very Low
Potency 2 5.00 Very Low Very Low Very Low
Chronic pancreatitis 1 5.00 Very Low Very Low Very Low
rheumatoid arthritis 1 5.00 Very Low Very Low Very Low
Osteoarthritis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 288 100.00 Very High Very High Very High
Cancer 362 99.96 Very High Very High Very High
Melanoma 657 99.84 Very High Very High Very High
Nevus 198 99.24 Very High Very High Very High
Death 44 98.62 Very High Very High Very High
Malignant Neoplastic Disease 90 98.04 Very High Very High Very High
Disease Progression 9 97.12 Very High Very High Very High
Lymphatic System Cancer 13 94.76 High High
Breast Cancer 12 94.36 High High
Disease 46 93.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased expression of XIAP has been shown to be associated with aggressive malignant behavior and disease progression in a number of malignancies, including lymphoma, breast cancer, lung cancer and renal cell carcinoma [18,25-27].
Positive_regulation (Increased) of Gene_expression (expression) of XIAP in lung associated with malignant neoplastic disease, lung cancer, lymphatic system cancer, renal cancer, breast cancer and disease progression
1) Confidence 0.64 Published 2007 Journal J Transl Med Section Body Doc Link PMC1796544 Disease Relevance 1.29 Pain Relevance 0
We showed that in our Carboplatin resistant cells, caspase-3 (the main effector caspase) was not activated by Carboplatin alone, yet pre-treatment of YUMAC cells with Phenoxodiol for 2 or 4 hours resulted in decreased levels of XIAP, sensitization to Carboplatin, and remarkable activation of caspase-3.
Positive_regulation (resulted) of Gene_expression (levels) of XIAP
2) Confidence 0.64 Published 2007 Journal J Transl Med Section Body Doc Link PMC1796544 Disease Relevance 0.68 Pain Relevance 0
In addition to caspase inhibition, XIAP has a role in activation of the JNK pathway, with resultant MAP kinase pathway activation, leading to NF-?
Positive_regulation (activation) of Gene_expression (has) of XIAP
3) Confidence 0.46 Published 2007 Journal J Transl Med Section Body Doc Link PMC1796544 Disease Relevance 0.68 Pain Relevance 0
Figure 1 shows regression plots for the two arrays assessed for XIAP expression (R = 0.7).
Positive_regulation (assessed) of Gene_expression (expression) of XIAP
4) Confidence 0.46 Published 2007 Journal J Transl Med Section Body Doc Link PMC1796544 Disease Relevance 0.81 Pain Relevance 0
We used S100 to define pixels as melanoma (tumor mask) within the array spot, and measured XIAP expression using Cy5-conjugated antibodies within the mask.
Positive_regulation (using) of Gene_expression (expression) of XIAP associated with cancer and melanoma
5) Confidence 0.46 Published 2007 Journal J Transl Med Section Abstract Doc Link PMC1796544 Disease Relevance 1.03 Pain Relevance 0
We conclude that XIAP levels in clinical specimens are significantly higher in melanomas than their benign counterparts, and higher in metastatic than in primary specimens, suggesting an association with malignant progression and disease aggression.
Positive_regulation (higher) of Gene_expression (levels) of XIAP associated with malignant neoplastic disease, melanoma, aggression and disease
6) Confidence 0.46 Published 2007 Journal J Transl Med Section Abstract Doc Link PMC1796544 Disease Relevance 1.39 Pain Relevance 0
XIAP expression was significantly higher in melanomas than nevi (P < 0.0001), and higher in metastatic than primary lesions (P < 0.0001).
Positive_regulation (higher) of Gene_expression (expression) of XIAP associated with melanoma and nevus
7) Confidence 0.43 Published 2007 Journal J Transl Med Section Abstract Doc Link PMC1796544 Disease Relevance 1.04 Pain Relevance 0
Further studies are needed to determine whether isoflavone analogues and direct XIAP targeting therapies can be used as chemotherapy sensitizers in melanoma patients, and whether XIAP expression levels are associated with response to therapy.



Spec (whether) Positive_regulation (associated) of Spec (whether) Gene_expression (expression) of XIAP associated with melanoma
8) Confidence 0.43 Published 2007 Journal J Transl Med Section Body Doc Link PMC1796544 Disease Relevance 0.64 Pain Relevance 0
A number of drugs that directly target XIAP are in development, including antisense oligonucleotide molecules (AEG 35156, Aegra pharmaceuticals, Montreal, Canada) and small molecule inhibitors, as reviewed by Schimmer et al [15], and these inhibitors might enhance chemosensitivity in XIAP over-expressing tumors.
Spec (might) Positive_regulation (enhance) of Gene_expression (expressing) of XIAP associated with cancer
9) Confidence 0.37 Published 2007 Journal J Transl Med Section Body Doc Link PMC1796544 Disease Relevance 1.34 Pain Relevance 0
B is then translocated into the nucleus where it binds to specific sequences of DNA and activates the expression of some anti-apoptosis genes, such as Bcl-2, Survivin, XIAP, and IAPs [15,16].
Positive_regulation (activates) of Gene_expression (expression) of XIAP in nucleus associated with apoptosis
10) Confidence 0.26 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2907730 Disease Relevance 0.94 Pain Relevance 0.06
In addition to survivin, there are several other intracellular proteins that are known to restrain cell death when highly expressed, such as, for example, Bcl-2, Bcl-xL, c-IAP2, XIAP, and FLIP, which also have been found overexpressed in some tumors [61].
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of XIAP associated with cancer and death
11) Confidence 0.21 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1479836 Disease Relevance 0.78 Pain Relevance 0.09

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