INT193106

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.80
First Reported 2006
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 2.13
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear chromosome (Birc5) chromosome segregation (Birc5) intracellular (Birc5)
enzyme binding (Birc5) embryo development (Birc5) cytoplasm (Birc5)
Anatomy Link Frequency
AsPC-1 1
Birc5 (Mus musculus)
Pain Link Frequency Relevance Heat
Taxol 2 96.44 Very High Very High Very High
Kinase C 1 74.40 Quite High
antagonist 1 34.88 Quite Low
cINOD 11 5.00 Very Low Very Low Very Low
palliative 3 5.00 Very Low Very Low Very Low
COX-2 inhibitor 3 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
metalloproteinase 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pancreatic Cancer 145 98.44 Very High Very High Very High
Apoptosis 203 97.84 Very High Very High Very High
Breast Cancer 74 90.88 High High
Cancer 193 77.48 Quite High
Adhesions 22 71.00 Quite High
Repression 4 69.64 Quite High
Metastasis 20 44.28 Quite Low
Glioma 1 40.64 Quite Low
Death 18 5.00 Very Low Very Low Very Low
Advanced Or Metastatic Breast Cancer 17 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inhibition of survivin phosphorylation by flavopiridol resulted in loss of survivin expression, and nonphos-phorylatable survivin exhibited accelerated clearance [31].
Phosphorylation (phosphorylation) of survivin
1) Confidence 0.80 Published 2008 Journal Breast Cancer Res Section Body Doc Link PMC2575526 Disease Relevance 0.45 Pain Relevance 0.09
Moreover, in Panc-1 cells, which had high expression of pFAK, specific inhibition of constitutive FAK phosphorylation by either RNAi or FRNK overexpression decreased the phosphorylation of Akt, reduced the levels of survivin expression and Bad phosphorylation at Ser136 and increased Gem-induced cytotoxicity and apoptosis.
Phosphorylation (phosphorylation) of survivin associated with apoptosis
2) Confidence 0.61 Published 2009 Journal Mol Cancer Section Abstract Doc Link PMC2806309 Disease Relevance 0.72 Pain Relevance 0
In conclusion, our research demonstrates for the first time that both constitutive and LN-induced FAK phosphorylation contribute to increased intrinsic chemoresistance to Gem in pancreatic cancer cell lines and these effects are partly due to the regulation of Akt and Bad phosphorylation and survivin expression.
Phosphorylation (phosphorylation) of survivin associated with pancreatic cancer
3) Confidence 0.61 Published 2009 Journal Mol Cancer Section Abstract Doc Link PMC2806309 Disease Relevance 0.36 Pain Relevance 0
Moreover, inhibition of FAK phosphorylation by FRNK overexpression antagonized the effects of LN on survivin expression and Bad phosphorylation at Ser136 in AsPC-1 cells (Fig. 10D).
Phosphorylation (phosphorylation) of survivin in AsPC-1
4) Confidence 0.61 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2806309 Disease Relevance 0.45 Pain Relevance 0
In particular, phosphorylation on threonine-34 of the survivin protein, which is accomplished by the cyclinB/cdk1 complex, leads to substantial extension of survivin's half-life during mitosis [73,74].
Phosphorylation (phosphorylation) of survivin protein
5) Confidence 0.03 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1479836 Disease Relevance 0.15 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox