INT193108

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Context Info
Confidence 0.42
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 5.25
Pain Relevance 0.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear chromosome (Birc5) chromosome segregation (Birc5) intracellular (Birc5)
enzyme binding (Birc5) embryo development (Birc5) cytoplasm (Birc5)
Birc5 (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 72 95.40 Very High Very High Very High
Inflammation 26 83.52 Quite High
COX-2 inhibitor 67 60.16 Quite High
cytokine 11 5.00 Very Low Very Low Very Low
Osteoarthritis 6 5.00 Very Low Very Low Very Low
rheumatoid arthritis 5 5.00 Very Low Very Low Very Low
antagonist 5 5.00 Very Low Very Low Very Low
Potency 5 5.00 Very Low Very Low Very Low
aspirin 4 5.00 Very Low Very Low Very Low
Paracetamol 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 376 99.60 Very High Very High Very High
Cancer 551 98.60 Very High Very High Very High
Non-small-cell Lung Cancer 8 95.64 Very High Very High Very High
Immunotherapy Of Cancer 6 90.64 High High
Death 77 89.20 High High
Repression 20 85.56 High High
INFLAMMATION 33 83.52 Quite High
Fever 41 81.92 Quite High
Colon Cancer 48 79.28 Quite High
Aneuploidy 5 77.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The extent of survivin down-regulation by celecoxib and DMC in different tumor cell lines is somewhat variable, but closely correlates with the degree of drug-induced growth inhibition and apoptosis.
Negative_regulation (regulation) of Negative_regulation (down) of survivin associated with cancer and apoptosis
1) Confidence 0.42 Published 2006 Journal Mol Cancer Section Abstract Doc Link PMC1479836 Disease Relevance 0.99 Pain Relevance 0.10
Indeed, when we compared the kinetics of survivin down-regulation with the resulting increase in apoptosis in two cell lines with varying sensitivities to DMC (Figure 5), we noticed a very close correlation between the degree of survivin down-regulation and the induction of apoptosis.
Negative_regulation (down) of Negative_regulation (regulation) of survivin associated with apoptosis
2) Confidence 0.42 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1479836 Disease Relevance 0.77 Pain Relevance 0.13
Down-regulation of survivin is independent of cyclooxygenase-2
Negative_regulation (Down) of Negative_regulation (regulation) of survivin
3) Confidence 0.42 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1479836 Disease Relevance 0.52 Pain Relevance 0
The extent of survivin down-regulation by celecoxib and DMC in different tumor cell lines is somewhat variable, but closely correlates with the degree of drug-induced growth inhibition and apoptosis.
Negative_regulation (down) of Negative_regulation (regulation) of survivin associated with cancer and apoptosis
4) Confidence 0.42 Published 2006 Journal Mol Cancer Section Abstract Doc Link PMC1479836 Disease Relevance 0.99 Pain Relevance 0.10
Indeed, when we compared the kinetics of survivin down-regulation with the resulting increase in apoptosis in two cell lines with varying sensitivities to DMC (Figure 5), we noticed a very close correlation between the degree of survivin down-regulation and the induction of apoptosis.
Negative_regulation (regulation) of Negative_regulation (down) of survivin associated with apoptosis
5) Confidence 0.42 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1479836 Disease Relevance 0.77 Pain Relevance 0.13
This effect was due to a down-regulation of MnSOD (superoxide dismutase containing manganese (Mn) and localized in mitochondria), a primary antioxidant protein and survivin, an anti-apoptotic protein (IAPS family member).
Negative_regulation (down) of Negative_regulation (regulation) of survivin associated with apoptosis
6) Confidence 0.42 Published 2010 Journal International Journal of Cell Biology Section Body Doc Link PMC2841246 Disease Relevance 1.21 Pain Relevance 0.07

General Comments

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