INT19316

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Context Info
Confidence 0.50
First Reported 1991
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 3.15
Pain Relevance 0.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Nppb) extracellular region (Nppb) nucleus (Nppb)
cytoplasm (Nppb)
Anatomy Link Frequency
ventricle 2
Nppb (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 8 100.00 Very High Very High Very High
Morphine 3 99.98 Very High Very High Very High
Spinal cord 5 95.16 Very High Very High Very High
Arthritis 2 88.84 High High
Angina 4 72.08 Quite High
cva 10 36.32 Quite Low
Central nervous system 2 5.00 Very Low Very Low Very Low
beta blocker 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 18 100.00 Very High Very High Very High
Systemic Sclerosis 8 99.70 Very High Very High Very High
Pulmonary Hypertension 18 99.04 Very High Very High Very High
Hypoxia 2 98.48 Very High Very High Very High
Obesity 36 96.40 Very High Very High Very High
Stress 6 96.06 Very High Very High Very High
Acute Coronary Syndrome 8 93.16 High High
Coronary Artery Disease 6 89.32 High High
Arthritis 2 88.84 High High
Myocardial Infarction 116 88.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Morphine stimulates secretion of ANP and BNP but by different ratios, suggesting different regulation systems for storage and secretion of ANP and BNP.
Positive_regulation (stimulates) of Localization (secretion) of BNP associated with morphine
1) Confidence 0.50 Published 1991 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 2043123 Disease Relevance 0.23 Pain Relevance 0.47
Indeed, a small study by Allonore et al. performed in 40 patients with systemic sclerosis suggests that NT-proBNP can be used as a screening tool for the early stage of PAH, when clinical symptoms are not present yet.73

NT-proBNP and Obesity

Positive_regulation (tool) of Localization (used) of NT-proBNP associated with pulmonary hypertension, obesity and systemic sclerosis
2) Confidence 0.44 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716780 Disease Relevance 1.78 Pain Relevance 0.04
However, when corrected for these factors in multivariate analysis, NT-proBNP remains an independent predictor.108 Secondly, other studies found elevations of BNP correlate with the size of ischemic myocardium, which is not necessarily stretch related;111,112 as well, recent studies from the stress testing literature show unequivocal evidence for elevations in both NT-proBNP and BNP in patients with ischemia but with normal LV function.113,114 Finally, Goetze et al. found in vitro, that the secretion of NT-proBNP in ischemia is mediated by a different pathway, triggered by hypoxia rather than myocardial stretch.115,116 Accordingly, in addition to valuable risk stratification in identifying those with an ACS on top of a dysfunctional ventricle, NT-proBNP levels may also reflect degree and extent of myocardial ischemia.
Positive_regulation (mediated) of Localization (secretion) of NT-proBNP in ventricle associated with stress, acute coronary syndrome, coronary artery disease, hypoxia and ischemia
3) Confidence 0.41 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716780 Disease Relevance 1.15 Pain Relevance 0.22

General Comments

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