INT19319

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Context Info
Confidence 0.42
First Reported 1991
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 3.42
Pain Relevance 1.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Agt) aging (Agt) extracellular region (Agt)
extracellular matrix organization (Agt)
Anatomy Link Frequency
gonadotroph 2
sympathetic 2
lung 2
oocytes 2
mast cell 2
Agt (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 68 99.04 Very High Very High Very High
cINOD 3 96.58 Very High Very High Very High
bradykinin 12 92.48 High High
gABA 15 91.28 High High
cytokine 22 89.40 High High
agonist 26 89.04 High High
Catecholamine 4 85.08 High High
lidocaine 1 82.44 Quite High
Bioavailability 4 79.12 Quite High
opiate 1 54.44 Quite High
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 18 98.08 Very High Very High Very High
Cough 10 97.64 Very High Very High Very High
Chronic Renal Failure 2 93.88 High High
Heart Rate Under Development 4 92.84 High High
Hypertension 120 91.80 High High
Necrosis 3 88.00 High High
Renal Disease 19 87.04 High High
Disorder Of Lipid Metabolism 1 84.00 Quite High
Acute Renal Failure 1 81.64 Quite High
Myocardial Infarction 95 81.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This new observation is in keeping with the demonstration of an important role for mast cell derived chymase in Ang II formation following either decreased expression [29] or pharmacological blockade of ACE [30] This finding also agrees with Prosser et al. [29] report that chymostatin completely inhibited Ang II formation from Ang-(1–12).
Negative_regulation (inhibited) of Ang II Binding (formation) of in mast cell
1) Confidence 0.42 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3018413 Disease Relevance 0.27 Pain Relevance 0
NSAIDs inhibit the synthesis of prostaglandins, and consequently vasoconstriction of the afferent arteriole leads to lowering of the glomerular filtration rate (GFR); captopril blocks the formation of angiotensin II (which also leads to a lower GFR), and should be used with caution in patients with stenotic renal arteries; cyclosporin causes vasoconstriction of the afferent arteriole, which is probably mediated by the sympathetic system.
Negative_regulation (blocks) of angiotensin II Binding (formation) of in sympathetic associated with cinod and increased venous pressure under development
2) Confidence 0.41 Published 1991 Journal Drug Saf Section Abstract Doc Link 2043284 Disease Relevance 1.19 Pain Relevance 0.26
It inhibits the binding of labeled angiotensin II to AT1 receptors in rat lung with a Ki of 3.7 nmol/L (Wienen et al 1993).
Negative_regulation (inhibits) of angiotensin II Binding (binding) of in lung
3) Confidence 0.23 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2293961 Disease Relevance 0 Pain Relevance 0.06
In addition to the differential effect of kinins, inhibition of angiotensin II formation with an ACE inhibitor diminishes the activity of both the AT1 and AT2 receptors.
Negative_regulation (inhibition) of angiotensin II Binding (formation) of
4) Confidence 0.22 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2291334 Disease Relevance 1.02 Pain Relevance 0
ARBs act by a different mechanism than ACE inhibitors by blocking the binding of angiotensin II to the AT1 receptor (Goodfriend et al 1996).
Negative_regulation (blocking) of angiotensin II Binding (binding) of
5) Confidence 0.22 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2291334 Disease Relevance 0.89 Pain Relevance 0.26
FK 739 inhibited the specific binding of [125I]-angiotensin II to rat aortic smooth muscle cell membrane with an IC50 value of 8.6 nM, but did not displace the specific binding of [125I]-angiotensin II to bovine cerebellum membrane.
Negative_regulation (inhibited) of angiotensin II Binding (binding) of in cerebellum
6) Confidence 0.16 Published 1993 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 8107326 Disease Relevance 0.05 Pain Relevance 0.09
Application of angiotensin II (10 nM) both in isolated glomerulosa cells and in oocytes injected with adrenal glomerulosa mRNA inhibited the K+ current at -100 mV.
Negative_regulation (inhibited) of angiotensin II Binding (Application) of in oocytes
7) Confidence 0.16 Published 2000 Journal Mol. Endocrinol. Section Abstract Doc Link 10847588 Disease Relevance 0 Pain Relevance 0.08
Well explored paracrine systems are: (i) the gonadotroph–lactotroph axis, of which the mediators remain incompletely defined but could be in part angiotensin II, PACAP, N-POMC and calcitonin; (ii) the gonadotroph–somatotroph axis, which is particularly well developed in fish; (ii) a cholinergic system in corticotrophs targeting somatotrophs, lactotrophs and FS cells; (iii) a GABA-ergic system in somatotrophs; (iv) several inhibitory systems targeting gonadotrophs (e.g. galanin and PRL from lactotrophs and ?
Negative_regulation (be) of angiotensin II Binding (part) of in gonadotroph associated with gaba
8) Confidence 0.11 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0 Pain Relevance 0.12
Substitutions in the extracellular domains of the human and rat receptor, which impaired the binding of angiotensin II, did not affect the binding of L-162,313.
Negative_regulation (impaired) of angiotensin II Binding (binding) of
9) Confidence 0.07 Published 1995 Journal J. Biol. Chem. Section Abstract Doc Link 7829475 Disease Relevance 0 Pain Relevance 0.36

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