INT193214

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Context Info
Confidence 0.08
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.51
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (PTGER2, PTGER4) signal transducer activity (PTGER2, PTGER4)
Anatomy Link Frequency
blood vessels 1
PTGER2 (Homo sapiens)
PTGER4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 54 99.40 Very High Very High Very High
antagonist 6 96.40 Very High Very High Very High
Inflammatory marker 3 17.40 Low Low
COX-2 inhibitor 52 5.00 Very Low Very Low Very Low
cINOD 18 5.00 Very Low Very Low Very Low
aspirin 12 5.00 Very Low Very Low Very Low
cytokine 11 5.00 Very Low Very Low Very Low
Inflammatory stimuli 3 5.00 Very Low Very Low Very Low
Paracetamol 3 5.00 Very Low Very Low Very Low
agonist 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Fever 41 100.00 Very High Very High Very High
INFLAMMATION 62 99.40 Very High Very High Very High
Colon Cancer 23 97.32 Very High Very High Very High
Cancer 126 94.20 High High
Adenocarcinoma 5 83.64 Quite High
Apoptosis 151 81.84 Quite High
Rhinitis 16 77.88 Quite High
Death 27 76.00 Quite High
Chronic Sinusitis 24 73.92 Quite High
Nasal Polyps 24 71.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunoreactivity for EP2 and EP4 was higher in inflammatory cells compared to epithelium, contrary to EP1 and EP3 staining, which was localized mainly in epithelial and sub-epithelial regions and blood vessels.


EP2 Binding (Immunoreactivity) of EP4 in blood vessels associated with inflammation
1) Confidence 0.08 Published 2006 Journal Respir Res Section Body Doc Link PMC1481584 Disease Relevance 0.64 Pain Relevance 0.13
In this cell type, PGE2 is associated with an increase of cAMP through EP4 receptor.
PGE2 Binding (associated) of EP4 receptor associated with fever
2) Confidence 0.03 Published 2010 Journal International Journal of Cell Biology Section Body Doc Link PMC2841246 Disease Relevance 1.86 Pain Relevance 0.05

General Comments

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