INT193215

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Context Info
Confidence 0.09
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.70
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (CYSLTR1, CYSLTR2) signal transducer activity (CYSLTR1, CYSLTR2) cellular_component (CYSLTR2)
Anatomy Link Frequency
nasal 1
CYSLTR1 (Homo sapiens)
CYSLTR2 (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 8 95.72 Very High Very High Very High
Inflammation 58 77.92 Quite High
chemokine 1 71.36 Quite High
agonist 27 51.76 Quite High
antagonist 9 39.28 Quite Low
Serotonin 14 5.00 Very Low Very Low Very Low
Inflammatory response 8 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
Inflammatory marker 3 5.00 Very Low Very Low Very Low
Inflammatory stimuli 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 19 99.32 Very High Very High Very High
Chronic Sinusitis 24 98.24 Very High Very High Very High
Nasal Polyps 24 97.32 Very High Very High Very High
Syndrome 1 94.92 High High
Edema 8 94.72 High High
Increased Venous Pressure Under Development 4 82.36 Quite High
INFLAMMATION 72 77.92 Quite High
Wheal 2 77.84 Quite High
Erythema 4 77.44 Quite High
Hypersensitivity 4 53.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interaction of cysteinyl leukotrienes receptors (CysLT1 and CysLT2) with theirs ligand LTC4, LTD4 and LTE4 play a disease-regulating role in chronic rhinosinusitis/nasal polyposis and particularly in the aspirin intolerance syndrome which is often correlated to these diseases.
LTD4 Binding (Interaction) of CysLT2 in nasal associated with aspirin, syndrome, chronic sinusitis, nasal polyps and disease
1) Confidence 0.09 Published 2006 Journal Respir Res Section Body Doc Link PMC1481584 Disease Relevance 0.71 Pain Relevance 0.16
CysLT2 binds both LTC4 and LTD4 with an affinity of approximately 10 nM, and both receptors bind LTE4 with affinities near 100 nM [24].
LTD4 Binding (binds) of CysLT2
2) Confidence 0.03 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2994686 Disease Relevance 0.40 Pain Relevance 0.03
In some endothelial populations, CysLT1 is much more abundant than CysLT2 and has affinities for LTD4 and LTC4 of approximately 1 nM and 10 nM, respectively.
CysLT1 Binding (abundant) of CysLT2
3) Confidence 0.02 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2994686 Disease Relevance 0.58 Pain Relevance 0.03

General Comments

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