INT193217

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Context Info
Confidence 0.10
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.31
Pain Relevance 0.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (PTGER2, PTGER3) signal transducer activity (PTGER2, PTGER3) nuclear envelope (PTGER3)
cell death (PTGER3) biological_process (PTGER3)
Anatomy Link Frequency
HT-29 1
immune cell 1
PTGER2 (Homo sapiens)
PTGER3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 29 95.04 Very High Very High Very High
Inflammatory stimuli 3 92.32 High High
withdrawal 7 86.24 High High
agonist 27 74.64 Quite High
antagonist 8 67.24 Quite High
aspirin 9 24.76 Low Low
cINOD 8 5.00 Very Low Very Low Very Low
Potency 4 5.00 Very Low Very Low Very Low
Inflammatory marker 3 5.00 Very Low Very Low Very Low
COX-2 inhibitor 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Nasal Polyps 24 97.76 Very High Very High Very High
Chronic Sinusitis 24 96.44 Very High Very High Very High
INFLAMMATION 38 95.04 Very High Very High Very High
Disease 15 62.80 Quite High
Polyps 3 61.72 Quite High
Colon Cancer 64 50.00 Quite Low
Rhinitis 16 50.00 Quite Low
Hypersensitivity 2 33.04 Quite Low
Apoptosis 17 5.00 Very Low Very Low Very Low
Asthma 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, and in contrast with the previous statement, interaction of PGE2 with EP1 and EP3 variants is translated in an increase of intracellular calcium, which can results in an induction of immune cell activation [29].
PGE2 Binding (interaction) of EP3 in immune cell
1) Confidence 0.10 Published 2006 Journal Respir Res Section Body Doc Link PMC1481584 Disease Relevance 1.31 Pain Relevance 0.28
These data supported the notion that PGE2 engages the EP3 receptor subtype to convey PTX sensitive proliferative signals via a reduction of cAMP levels in HT-29 cells.


PGE2 Binding (engages) of EP3 in HT-29
2) Confidence 0.10 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2615781 Disease Relevance 0 Pain Relevance 0.15

General Comments

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