INT193218

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Context Info
Confidence 0.12
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.31
Pain Relevance 0.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (PTGER1, PTGER2) signal transducer activity (PTGER1, PTGER2)
Anatomy Link Frequency
immune cell 1
PTGER1 (Homo sapiens)
PTGER2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 37 95.04 Very High Very High Very High
Inflammatory stimuli 3 92.32 High High
cytokine 10 81.16 Quite High
Osteoarthritis 39 75.08 Quite High
agonist 27 74.64 Quite High
Pain 2 66.00 Quite High
Arthritis 2 55.36 Quite High
aspirin 9 54.08 Quite High
cINOD 9 53.44 Quite High
metalloproteinase 18 46.00 Quite Low
Disease Link Frequency Relevance Heat
Nasal Polyps 24 97.76 Very High Very High Very High
Chronic Sinusitis 24 96.44 Very High Very High Very High
INFLAMMATION 46 95.04 Very High Very High Very High
Colon Cancer 64 93.48 High High
Cancer 5 91.76 High High
Hypertrophy 22 81.80 Quite High
Osteoarthritis 51 75.08 Quite High
Pain 2 66.00 Quite High
Apoptosis 19 65.32 Quite High
Disease 19 62.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PGE2 exerts its biological functions via binding to four types of G-protein-coupled receptors termed EP1-4 [13,14], which couple to distinct downstream second messenger systems.
EP1 Binding (binding) of PGE2
1) Confidence 0.12 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2615781 Disease Relevance 0.53 Pain Relevance 0.23
However, and in contrast with the previous statement, interaction of PGE2 with EP1 and EP3 variants is translated in an increase of intracellular calcium, which can results in an induction of immune cell activation [29].
EP1 Binding (interaction) of PGE2 in immune cell
2) Confidence 0.11 Published 2006 Journal Respir Res Section Body Doc Link PMC1481584 Disease Relevance 1.30 Pain Relevance 0.28
It is well established that EP1 and EP2 receptors for PGE2 are low-affinity receptors, whereas EP3 and EP4 are high-affinity receptors.
EP1 Binding (receptors) of PGE2
3) Confidence 0.10 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206385 Disease Relevance 0.47 Pain Relevance 0.15

General Comments

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