INT193219

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Context Info
Confidence 0.28
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.20
Pain Relevance 0.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (LTC4S) small molecule metabolic process (LTC4S) lyase activity (LTC4S)
endoplasmic reticulum (LTC4S) signal transducer activity (CYSLTR2) lipid binding (LTC4S)
Anatomy Link Frequency
nasal 1
LTC4S (Homo sapiens)
CYSLTR2 (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 39 98.04 Very High Very High Very High
cINOD 4 80.32 Quite High
Inflammation 33 77.92 Quite High
chemokine 1 70.88 Quite High
COX2 2 41.76 Quite Low
antagonist 6 38.80 Quite Low
Inflammatory marker 3 5.00 Very Low Very Low Very Low
Inflammatory stimuli 3 5.00 Very Low Very Low Very Low
adenocard 1 5.00 Very Low Very Low Very Low
Antihistamine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Urticaria 20 99.32 Very High Very High Very High
Disease 16 99.08 Very High Very High Very High
Chronic Sinusitis 25 98.00 Very High Very High Very High
Asthma 76 97.84 Very High Very High Very High
Nasal Polyps 26 97.08 Very High Very High Very High
Pressure And Volume Under Development 44 96.28 Very High Very High Very High
Syndrome 1 94.68 High High
Hypersensitivity 6 81.04 Quite High
INFLAMMATION 39 77.92 Quite High
Rhinitis 19 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mastalerz et al. demonstrated the overproduction of Cys-LT in association with the LTC4S polymorphism in chronic urticaria patients with aspirin sensitivity.34 The frequency of subjects carrying the C allele of LTC4S-444A > C was significantly higher in chronic urticaria patients who tested positive in the aspirin challenge test than those who tested negative.
LTC4S Binding (association) of Cys-LT associated with urticaria and aspirin
1) Confidence 0.28 Published 2006 Journal Yonsei Medical Journal Section Body Doc Link PMC2687575 Disease Relevance 1.49 Pain Relevance 0.29
Interaction of cysteinyl leukotrienes receptors (CysLT1 and CysLT2) with theirs ligand LTC4, LTD4 and LTE4 play a disease-regulating role in chronic rhinosinusitis/nasal polyposis and particularly in the aspirin intolerance syndrome which is often correlated to these diseases.
LTC4 Binding (Interaction) of CysLT2 in nasal associated with aspirin, syndrome, chronic sinusitis, nasal polyps and disease
2) Confidence 0.02 Published 2006 Journal Respir Res Section Body Doc Link PMC1481584 Disease Relevance 0.71 Pain Relevance 0.16

General Comments

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