INT193254

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Context Info
Confidence 0.15
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.93
Pain Relevance 0.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (CYSLTR2) cellular_component (CYSLTR2) signal transducer activity (CYSLTR2)
Anatomy Link Frequency
eosinophils 1
CYSLTR2 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 30 95.04 Very High Very High Very High
Inflammation 43 92.80 High High
Neurotransmitter 2 59.76 Quite High
Dopamine 6 57.44 Quite High
Opioid 2 55.44 Quite High
Glutamate 2 53.84 Quite High
Inflammatory marker 3 44.24 Quite Low
antagonist 17 43.32 Quite Low
Hippocampus 12 5.00 Very Low Very Low Very Low
aspirin 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rhinitis 16 93.84 High High
INFLAMMATION 53 92.80 High High
Edema 4 89.72 High High
Increased Venous Pressure Under Development 2 77.36 Quite High
Nasal Polyps 24 77.24 Quite High
Wheal 1 72.84 Quite High
Erythema 2 72.44 Quite High
Bordatella Infection 14 57.92 Quite High
Malaria 4 50.00 Quite Low
Hypersensitivity 3 48.92 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
S binding in membranes from CysLT2-transfected HEK293 cells (Figure 7C).
CysLT2 Binding (binding) of
1) Confidence 0.15 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2839267 Disease Relevance 0 Pain Relevance 0
S binding to membranes isolated from either CysLT2- or pcDNA3-transfected cells (Figure 7C).
CysLT2 Binding (binding) of
2) Confidence 0.13 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2839267 Disease Relevance 0.06 Pain Relevance 0.23
protein concentrations (CysLT1: rho = 0,574, p = 0.01; CysLT2: rho = 0,523; p < 0.05), ECP (CysLT1: rho = 0,544, p = 0.02; CysLT2: rho = 0,413; p = 0.03) and the total number of activated eosinophils (CysLT1: rho = 0,546, p = 0.02; CysLT2: rho = 0,614; p = 0.03).
CysLT2 Binding (0.03) of in eosinophils
3) Confidence 0.12 Published 2006 Journal Respir Res Section Body Doc Link PMC1481584 Disease Relevance 0.47 Pain Relevance 0.12
CysLT2 binds both LTC4 and LTD4 with an affinity of approximately 10 nM, and both receptors bind LTE4 with affinities near 100 nM [24].
CysLT2 Binding (binds) of
4) Confidence 0.07 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2994686 Disease Relevance 0.40 Pain Relevance 0.03

General Comments

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