INT193257

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Context Info
Confidence 0.18
First Reported 2006
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.81
Pain Relevance 0.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (CYSLTR2) cellular_component (CYSLTR2) signal transducer activity (CYSLTR2)
CYSLTR2 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 30 92.72 High High
Inflammation 43 75.00 Quite High
antagonist 17 51.52 Quite High
Neurotransmitter 2 38.96 Quite Low
Dopamine 6 36.64 Quite Low
Opioid 2 34.64 Quite Low
Glutamate 2 33.04 Quite Low
Hippocampus 12 5.00 Very Low Very Low Very Low
aspirin 8 5.00 Very Low Very Low Very Low
Serotonin 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Edema 4 97.84 Very High Very High Very High
Increased Venous Pressure Under Development 2 85.48 High High
Disease 17 85.36 High High
Wheal 1 80.96 Quite High
Erythema 2 80.56 Quite High
Rhinitis 16 77.04 Quite High
INFLAMMATION 53 75.00 Quite High
Chronic Sinusitis 24 74.88 Quite High
Bordatella Infection 14 66.96 Quite High
Paranasal Sinus Disease 1 62.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
q-coupled CysLT2 nor the G?
Neg (nor) Positive_regulation (coupled) of CysLT2
1) Confidence 0.18 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2839267 Disease Relevance 0.07 Pain Relevance 0.08
CysLT1 mRNA expression was significantly increased in CRS-NP compared to CRS and controls, and CRS compared to controls, whereas CysLT2 mRNA was enhanced in both CRS groups without differences between them.
Positive_regulation (enhanced) of CysLT2 mRNA
2) Confidence 0.17 Published 2006 Journal Respir Res Section Abstract Doc Link PMC1481584 Disease Relevance 1.13 Pain Relevance 0.13
In contrast to this observation, in the parallel control experiment LTD4 dose-dependently activated CysLT2 with an EC50 value of 3.1 nM (Figure 7B).
Positive_regulation (activated) of CysLT2
3) Confidence 0.17 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2839267 Disease Relevance 0 Pain Relevance 0.03
The CysLT receptors, CysLT1 and CysLT2, are distributed in numerous tissues.
Positive_regulation (distributed) of CysLT2
4) Confidence 0.10 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2994686 Disease Relevance 0.61 Pain Relevance 0.03

General Comments

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