INT193264

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Context Info
Confidence 0.30
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.96
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (CYSLTR1) signal transducer activity (CYSLTR1)
Anatomy Link Frequency
epithelial cells 2
CYSLTR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammatory marker 3 86.48 High High
aspirin 39 65.84 Quite High
Inflammation 33 50.00 Quite Low
COX2 2 47.00 Quite Low
antagonist 6 5.00 Very Low Very Low Very Low
cINOD 4 5.00 Very Low Very Low Very Low
Inflammatory stimuli 3 5.00 Very Low Very Low Very Low
adenocard 1 5.00 Very Low Very Low Very Low
Antihistamine 1 5.00 Very Low Very Low Very Low
chemokine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Asthma 76 99.48 Very High Very High Very High
INFLAMMATION 39 86.48 High High
Rhinitis 19 82.72 Quite High
Nasal Polyps 26 56.32 Quite High
Pressure And Volume Under Development 44 5.00 Very Low Very Low Very Low
Chronic Sinusitis 25 5.00 Very Low Very Low Very Low
Urticaria 20 5.00 Very Low Very Low Very Low
Disease 16 5.00 Very Low Very Low Very Low
Hypersensitivity 6 5.00 Very Low Very Low Very Low
Polyps 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On the other hand CysLT1 and CysLT2 mRNA levels were similar in CRS and normal mucosa, however significantly higher concentrations of CysLT1 compared to CysLT2 were observed in the CRS-NP group.


Regulation (similar) of Gene_expression (levels) of CysLT1
1) Confidence 0.30 Published 2006 Journal Respir Res Section Body Doc Link PMC1481584 Disease Relevance 0.31 Pain Relevance 0.08
A functional study using two cell lines, human T lymphocytes (Jurkat) and lung epithelial cells (A549), showed enhanced promoter activity with the ht2 [T-C-G] construct compared to the ht1 [C-A-A] construct, suggesting that this polymorphism modulates CYSLTR1 expression to increase AIA susceptibility.
Regulation (modulates) of Gene_expression (expression) of CYSLTR1 in epithelial cells associated with asthma
2) Confidence 0.26 Published 2006 Journal Yonsei Medical Journal Section Body Doc Link PMC2687575 Disease Relevance 0.66 Pain Relevance 0.03

General Comments

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