INT193268

Context Info Confidence 0.03 First Reported 2006 Last Reported 2006 Negated 0 Speculated 1 Reported most in Body Documents 3 Total Number 5 Disease Relevance 1.56 Pain Relevance 2.67

plasma membrane (Brs3) signal transducer activity (Brs3)

Anatomy Link Frequency afferent neurons 1 Brs3 (Rattus norvegicus)

Pain Link Frequency Relevance Heat qutenza 240 100.00 c fibre 48 88.80 sodium channel 19 79.36 unmyelinated 6 77.96 Central nervous system 6 74.88 fibrosis 2 73.28 depression 6 28.88 Action potential 34 5.00 agonist 25 5.00 Spinal cord 6 5.00

Disease Link Frequency Relevance Heat Bundle-branch Block 8 97.92 Disease 14 97.28 Stress 2 90.88 Toxicity 3 83.04 Heart Arrhythmia 20 77.92 Heart Rate Under Development 20 77.80 Recurrence 8 77.00 Apoptosis 2 73.88 Fibrosis 2 73.28 Dilated Cardiomyopathy 6 66.56

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Such A-type BRs are likely typical of a broad association for cranial visceral afferent neurons with CAP sensitivity.

BRs Spec (likely) Binding (association) of in afferent neurons associated with qutenza

1) Confidence 0.03 Published 2006 Journal J Negat Results Biomed Section Body Doc Link PMC1481593 Disease Relevance 0.06 Pain Relevance 0.86

Despite these limitations of the single fiber BR recordings, the ADN ENG results bolster the association of C-type BRs with CAP sensitivity and A-type BRs with CAP resistance consistent with other studies [27].

BRs Binding (association) of associated with qutenza

2) Confidence 0.03 Published 2006 Journal J Negat Results Biomed Section Body Doc Link PMC1481593 Disease Relevance 0.14 Pain Relevance 0.83

Despite these limitations of the single fiber BR recordings, the ADN ENG results bolster the association of C-type BRs with CAP sensitivity and A-type BRs with CAP resistance consistent with other studies [27].

BRs Binding (association) of associated with qutenza

3) Confidence 0.03 Published 2006 Journal J Negat Results Biomed Section Body Doc Link PMC1481593 Disease Relevance 0.15 Pain Relevance 0.89

BrS is characterized by a typical ECG pattern of incomplete or complete right bundle branch block and ST segment elevation (?

BrS Binding (characterized) of associated with bundle-branch block

4) Confidence 0.02 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1592481 Disease Relevance 0.67 Pain Relevance 0.04

As of January 2006, approximately 160 SCN5A mutations had been reported[33], and approximately 65% of them are associated with a BrS phenotype, but no specific clustering within the coding region is demonstrable.

BrS Binding (associated) of

5) Confidence 0.02 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1592481 Disease Relevance 0.53 Pain Relevance 0.04

General Comments

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