INT193269

Context Info Confidence 0.03 First Reported 2006 Last Reported 2006 Negated 0 Speculated 1 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0.26 Pain Relevance 0.79

plasma membrane (Brs3) signal transducer activity (Brs3)

Brs3 (Rattus norvegicus)

Pain Link Frequency Relevance Heat qutenza 80 99.90 Action potential 12 94.64 c fibre 16 71.44 local anesthetic 2 64.60 potassium channel 2 63.56 sodium channel 9 58.56 agonist 9 5.00 Spinal cord 2 5.00 Central nervous system 2 5.00 cva 2 5.00

Disease Link Frequency Relevance Heat Arrhythmogenic Right Ventricular Dysplasia 3 77.28 Heart Arrhythmia 10 76.48 Syncope 8 56.08 Nociception 2 54.88 Arrhythmia Under Development 2 48.16 Heart Rate Under Development 10 44.48 Shock 5 20.48 Recurrence 4 17.92 Disease 7 5.00 Arrhythmias 2 Under Development 5 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Thus, non-specific actions of CAP may depress a range of ion channels indirectly in A-type BRs lacking TRPV1 expression.

Spec (may) Negative_regulation (depress) of BRs associated with qutenza

1) Confidence 0.03 Published 2006 Journal J Negat Results Biomed Section Body Doc Link PMC1481593 Disease Relevance 0.05 Pain Relevance 0.71

This proposal is based on the idea that the loss of sodium inward current in BrS, tilts the balance between outward and inward currents, with an abnormal shift in the outward direction at the end of phase 1 of the action potential.

Negative_regulation (loss) of BrS associated with action potential

2) Confidence 0.03 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1592481 Disease Relevance 0.21 Pain Relevance 0.08

General Comments

This test has worked.