INT193269

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Context Info
Confidence 0.03
First Reported 2006
Last Reported 2006
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.26
Pain Relevance 0.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Brs3) signal transducer activity (Brs3)
Brs3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
qutenza 80 99.90 Very High Very High Very High
Action potential 12 94.64 High High
c fibre 16 71.44 Quite High
local anesthetic 2 64.60 Quite High
potassium channel 2 63.56 Quite High
sodium channel 9 58.56 Quite High
agonist 9 5.00 Very Low Very Low Very Low
Spinal cord 2 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
cva 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Arrhythmogenic Right Ventricular Dysplasia 3 77.28 Quite High
Heart Arrhythmia 10 76.48 Quite High
Syncope 8 56.08 Quite High
Nociception 2 54.88 Quite High
Arrhythmia Under Development 2 48.16 Quite Low
Heart Rate Under Development 10 44.48 Quite Low
Shock 5 20.48 Low Low
Recurrence 4 17.92 Low Low
Disease 7 5.00 Very Low Very Low Very Low
Arrhythmias 2 Under Development 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, non-specific actions of CAP may depress a range of ion channels indirectly in A-type BRs lacking TRPV1 expression.
Spec (may) Negative_regulation (depress) of BRs associated with qutenza
1) Confidence 0.03 Published 2006 Journal J Negat Results Biomed Section Body Doc Link PMC1481593 Disease Relevance 0.05 Pain Relevance 0.71
This proposal is based on the idea that the loss of sodium inward current in BrS, tilts the balance between outward and inward currents, with an abnormal shift in the outward direction at the end of phase 1 of the action potential.
Negative_regulation (loss) of BrS associated with action potential
2) Confidence 0.03 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1592481 Disease Relevance 0.21 Pain Relevance 0.08

General Comments

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