INT193271

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Context Info
Confidence 0.05
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 1.25
Pain Relevance 5.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Brs3) signal transducer activity (Brs3)
Anatomy Link Frequency
cranial 1
Brs3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
qutenza 560 100.00 Very High Very High Very High
c fibre 112 96.64 Very High Very High Very High
agonist 51 93.40 High High
local anesthetic 8 85.64 High High
potassium channel 8 84.60 Quite High
sodium channel 15 79.60 Quite High
Action potential 72 72.28 Quite High
depression 14 65.28 Quite High
Spinal cord 14 5.00 Very Low Very Low Very Low
Central nervous system 14 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Heart Rate Under Development 10 98.64 Very High Very High Very High
Syncope 8 97.68 Very High Very High Very High
Nociception 14 96.00 Very High Very High Very High
Arrhythmias 2 Under Development 5 92.88 High High
Sudden Death 4 89.92 High High
Heart Arrhythmia 10 89.04 High High
Disease 7 87.32 High High
Myocardial Infarction 3 84.96 Quite High
Ventricular Tachycardia 3 83.96 Quite High
Bundle-branch Block 4 81.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However in A-type BRs, the high concentrations of CAP produced multiple, global changes in the pressure-discharge relations, changes that are consistent with multiple targets of action.
Gene_expression (produced) of BRs associated with qutenza
1) Confidence 0.05 Published 2006 Journal J Negat Results Biomed Section Body Doc Link PMC1481593 Disease Relevance 0 Pain Relevance 0.89
M CAP did not alter any aspect of the pressure-discharge properties of such regularly discharging BRs even after 15 min (Figure 2).
Gene_expression (discharging) of BRs associated with qutenza
2) Confidence 0.05 Published 2006 Journal J Negat Results Biomed Section Body Doc Link PMC1481593 Disease Relevance 0 Pain Relevance 0.58
We tested much higher concentrations of CAP in otherwise CAP-resistant, A-type BRs (# 10 ?
Gene_expression (resistant) of BRs associated with qutenza
3) Confidence 0.05 Published 2006 Journal J Negat Results Biomed Section Body Doc Link PMC1481593 Disease Relevance 0.07 Pain Relevance 1.21
Within these limits, ADN BRs conduct within similar ranges of both the A?
Gene_expression (conduct) of BRs
4) Confidence 0.05 Published 2006 Journal J Negat Results Biomed Section Body Doc Link PMC1481593 Disease Relevance 0.10 Pain Relevance 0.71
We tested much higher concentrations of CAP in otherwise CAP-resistant, A-type BRs (# 10 ?
Gene_expression (otherwise) of BRs associated with qutenza
5) Confidence 0.05 Published 2006 Journal J Negat Results Biomed Section Body Doc Link PMC1481593 Disease Relevance 0.07 Pain Relevance 1.21
On average (n = 10), the discharge properties of regularly discharging BRs were unaltered by 1 ?
Gene_expression (discharging) of BRs
6) Confidence 0.05 Published 2006 Journal J Negat Results Biomed Section Body Doc Link PMC1481593 Disease Relevance 0 Pain Relevance 0.57
C-type aortic BRs express TRPV1 in their peripheral axons and in their aortic arch terminations and appear to be part of a broader group of cranial visceral afferents that are known to be CAP-sensitive and centrally provide for respiratory and gastrointestinal as well as cardiovascular regulation [43,44].
Gene_expression (express) of BRs in cranial associated with qutenza
7) Confidence 0.04 Published 2006 Journal J Negat Results Biomed Section Body Doc Link PMC1481593 Disease Relevance 0.14 Pain Relevance 0.67
Syncope, typically occurring at rest or during sleep (in individuals in their third or fourth decades of life) is a common presentation of BrS.
Gene_expression (presentation) of BrS associated with syncope
8) Confidence 0.04 Published 2006 Journal Orphanet J Rare Dis Section Abstract Doc Link PMC1592481 Disease Relevance 0.88 Pain Relevance 0.03

General Comments

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