INT193281
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
CAP Index has an additional association with survival, good neurological outcome, and lack of need for interventions to lower ICP, independent of ICP and CPP. | |||||||||||||||
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Good neurological outcome is independently associated with CAP Index (p = 0.0001), but not CPP (p = 0.29). | |||||||||||||||
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Survival is independently associated with CAP Index and CPP (p = 0.0001). | |||||||||||||||
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M concentration of CAP is close to the KD (2 ? | |||||||||||||||
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CAP was initially dissolved in DMSO and then mixed with PBS to a concentrated stock solution containing 300 ? | |||||||||||||||
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M CAP, the BR was nearly inexcitable and only fired a scattering of action potentials to aortic arch pressures above its control threshold level (Figure 3). | |||||||||||||||
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Despite the variety of their structural characteristics, HDAC inhibitors can be broadly characterized by a common pharmacophore model which consists in a surface domain (also named CAP), which is able to interact with the rim space at the entrance of the catalytic tunnel of the enzyme, linked to a hydrophobic spacer through a polar connection unit. | |||||||||||||||
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According to the pharmacophore model, the hydroxamic group chelates the zinc atom at the active site of HDACs, while a hydrophobic cap and an aliphatic side chain respectively, interacts with the edge and fits into the hydrophobic catalytic pocket [89, 90]. | |||||||||||||||
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General Comments
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