INT193281

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Context Info
Confidence 0.07
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 4.57
Pain Relevance 3.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CAP1) cell morphogenesis (CAP1) plasma membrane (CAP1)
cytoskeleton organization (CAP1) cytoplasm (CAP1)
Anatomy Link Frequency
rim 1
aortic arch 1
edge 1
CAP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 240 100.00 Very High Very High Very High
agonist 27 99.96 Very High Very High Very High
cva 408 99.36 Very High Very High Very High
Action potential 30 99.32 Very High Very High Very High
c fibre 48 86.64 High High
Bioavailability 12 65.28 Quite High
Potency 8 64.96 Quite High
anticonvulsant 2 40.00 Quite Low
alcohol 3 22.48 Low Low
cerebral cortex 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cv General 3 Under Development 399 99.36 Very High Very High Very High
Death 20 94.32 High High
Liver Failure 2 89.08 High High
Cancer 94 88.80 High High
Pancytopenia 2 87.12 High High
Toxicity 29 86.16 High High
Tremor 2 83.72 Quite High
Dizziness 4 83.24 Quite High
Sleep Disorders 15 82.80 Quite High
Apoptosis 26 65.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CAP Index has an additional association with survival, good neurological outcome, and lack of need for interventions to lower ICP, independent of ICP and CPP.
CAP Binding (association) of associated with cva
1) Confidence 0.07 Published 2006 Journal Crit Care Section Body Doc Link PMC1794465 Disease Relevance 1.35 Pain Relevance 0.57
Good neurological outcome is independently associated with CAP Index (p = 0.0001), but not CPP (p = 0.29).
CAP Binding (associated) of
2) Confidence 0.07 Published 2006 Journal Crit Care Section Body Doc Link PMC1794465 Disease Relevance 1.13 Pain Relevance 0.50
Survival is independently associated with CAP Index and CPP (p = 0.0001).
CAP Binding (associated) of
3) Confidence 0.06 Published 2006 Journal Crit Care Section Body Doc Link PMC1794465 Disease Relevance 1.08 Pain Relevance 0.49
M concentration of CAP is close to the KD (2 ?
CAP Binding (concentration) of associated with qutenza
4) Confidence 0.05 Published 2006 Journal J Negat Results Biomed Section Body Doc Link PMC1481593 Disease Relevance 0 Pain Relevance 0.63
CAP was initially dissolved in DMSO and then mixed with PBS to a concentrated stock solution containing 300 ?
CAP Binding (dissolved) of associated with qutenza
5) Confidence 0.05 Published 2006 Journal J Negat Results Biomed Section Body Doc Link PMC1481593 Disease Relevance 0 Pain Relevance 0.49
M CAP, the BR was nearly inexcitable and only fired a scattering of action potentials to aortic arch pressures above its control threshold level (Figure 3).
CAP Binding (fired) of in aortic arch associated with action potential and qutenza
6) Confidence 0.05 Published 2006 Journal J Negat Results Biomed Section Body Doc Link PMC1481593 Disease Relevance 0 Pain Relevance 0.79
Despite the variety of their structural characteristics, HDAC inhibitors can be broadly characterized by a common “pharmacophore” model which consists in a surface domain (also named “CAP”), which is able to interact with the rim space at the entrance of the catalytic tunnel of the enzyme, linked to a hydrophobic spacer through a polar connection unit.
CAP Binding (interact) of in rim
7) Confidence 0.03 Published 2008 Journal Current Medicinal Chemistry Section Body Doc Link PMC2764862 Disease Relevance 0.19 Pain Relevance 0.03
According to the pharmacophore model, the hydroxamic group chelates the zinc atom at the active site of HDACs, while a hydrophobic cap and an aliphatic side chain respectively, interacts with the edge and fits into the hydrophobic catalytic pocket [89, 90].
cap Binding (interacts) of in edge
8) Confidence 0.02 Published 2008 Journal Current Medicinal Chemistry Section Body Doc Link PMC2764862 Disease Relevance 0.82 Pain Relevance 0.03

General Comments

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