INT19330

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Context Info
Confidence 0.48
First Reported 1982
Last Reported 2010
Negated 2
Speculated 4
Reported most in Abstract
Documents 99
Total Number 103
Disease Relevance 76.26
Pain Relevance 22.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (HLA-A)
Anatomy Link Frequency
leukocyte 24
joint 2
thyroid 2
skin 2
optic 2
HLA-A (Homo sapiens)
Pain Link Frequency Relevance Heat
Arthritis 532 100.00 Very High Very High Very High
spinal inflammation 294 100.00 Very High Very High Very High
psoriasis 265 100.00 Very High Very High Very High
rheumatoid arthritis 151 100.00 Very High Very High Very High
postherpetic neuralgia 11 99.76 Very High Very High Very High
Snapping jaw 23 99.66 Very High Very High Very High
endometriosis 12 99.58 Very High Very High Very High
carpal tunnel syndrome 2 99.44 Very High Very High Very High
Chronic pancreatitis 5 99.20 Very High Very High Very High
Multiple sclerosis 120 98.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
Disease 620 100.00 Very High Very High Very High
Seronegative Spondarthritis 426 100.00 Very High Very High Very High
Low Back Pain 312 100.00 Very High Very High Very High
Psoriasis 267 100.00 Very High Very High Very High
Syndrome 176 100.00 Very High Very High Very High
Rheumatoid Arthritis 156 100.00 Very High Very High Very High
Pancreatitis 10 100.00 Very High Very High Very High
Mucocutaneous Lymph Node Syndrome 415 99.92 Very High Very High Very High
Melanoma 39 99.92 Very High Very High Very High
Celiac Disease 19 99.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interaction between HLA-DR2 and abnormal brain MRI in optic neuritis and early MS.
HLA Binding (Interaction) of in optic associated with optic neuritis and neuritis
1) Confidence 0.48 Published 2000 Journal Neurology Section Title Doc Link 10802800 Disease Relevance 0.38 Pain Relevance 0.29
The association of the human leukocyte antigen (HLA)-DR2 allele with brain MRI signal abnormalities and with the development of MS was assessed in 178 patients enrolled in the Optic Neuritis Treatment Trial.
HLA Binding (association) of in brain associated with congenital anomalies, optic neuritis and neuritis
2) Confidence 0.48 Published 2000 Journal Neurology Section Abstract Doc Link 10802800 Disease Relevance 0.34 Pain Relevance 0.24
Linkage to HLA-A and lack of disease association.
HLA-A Binding (Linkage) of associated with disease
3) Confidence 0.47 Published 1989 Journal Arthritis Rheum. Section Title Doc Link 2568835 Disease Relevance 0.87 Pain Relevance 0.56
Complementation with HLA-A and HLA-D locus alleles in ankylosing spondylitis with peripheral arthritis.
HLA-A Binding (Complementation) of associated with spinal inflammation and arthritis
4) Confidence 0.47 Published 1985 Journal J. Rheumatol. Section Title Doc Link 3876437 Disease Relevance 0.63 Pain Relevance 0.33
This study was performed to determine whether the susceptibility to advanced endometriosis is also associated with HLA-A, B antigens in the Korean population, which is the closest ethnic group to Japanese.
HLA-A Binding (associated) of associated with endometriosis
5) Confidence 0.47 Published 2008 Journal The Korean journal of laboratory medicine Section Abstract Doc Link 18458507 Disease Relevance 0.86 Pain Relevance 0.34
[Association of HLA-A, B antigens with susceptibility to advanced endometriosis in Koreans].
HLA-A Binding (Association) of associated with endometriosis
6) Confidence 0.47 Published 2008 Journal The Korean journal of laboratory medicine Section Title Doc Link 18458507 Disease Relevance 0.90 Pain Relevance 0.36
No significant association between any HLA-A, -B, or -DR and eosinophilic fasciitis was seen.
HLA-A Neg (No) Binding (association) of associated with rhinitis and fasciitis
7) Confidence 0.47 Published 1988 Journal Semin. Arthritis Rheum. Section Abstract Doc Link 3232080 Disease Relevance 1.47 Pain Relevance 0.12
CONCLUSIONS: The findings of the present study suggest that the susceptibility to advanced endometriosis, unlike in the Japanese population, is not associated with HLA-A, B antigens in the Korean population.


HLA-A Binding (associated) of
8) Confidence 0.47 Published 2008 Journal The Korean journal of laboratory medicine Section Body Doc Link 18458507 Disease Relevance 0 Pain Relevance 0
Ankylosing spondylitis, acute anterior uveitis and reactive arthritides, including enteroarthritis and uroarthritis , are all associated with the human leucocyte antigen (HLA) B27.
HLA Binding (associated) of in leucocyte associated with spinal inflammation, reiter's syndrome and uveitis
9) Confidence 0.42 Published 1984 Journal Ann. Clin. Res. Section Abstract Doc Link 6378047 Disease Relevance 0.95 Pain Relevance 0.29
The association with B27 is particularly strong in PsA patients with sacroiliitis, but it has also been detected in patients with distal interphalangeal joint involvement, suggesting that the HLA-B27 association may not simply reflect the co-incidence of ankylosing spondylitis with psoriasis [31].
HLA Binding (association) of in joint associated with psoriasis, spinal inflammation, sacroiliitis and arthritis
10) Confidence 0.40 Published 2002 Journal Arthritis Res Section Body Doc Link PMC128931 Disease Relevance 1.65 Pain Relevance 0.82
One study investigating linkage in affected sibling pair families with psoriasis has suggested that linkage to the HLA gene region is stronger in those families without joint involvement, although no attempt was made to make a diagnosis of PsA [18].
HLA Binding (linkage) of in joint associated with psoriasis and arthritis
11) Confidence 0.40 Published 2002 Journal Arthritis Res Section Body Doc Link PMC128931 Disease Relevance 1.28 Pain Relevance 0.61
The aims of this study were to determine whether any HLA phenotypes are associated either with Celtic or non-Celtic ancestry, or skin type.
HLA Binding (associated) of in skin
12) Confidence 0.40 Published 1998 Journal Br. J. Dermatol. Section Abstract Doc Link 9640367 Disease Relevance 0.26 Pain Relevance 0
The peptides that bind to HLA class I molecules are restricted in length and often contain key amino acids (anchor residues) at certain positions.
HLA Binding (bind) of
13) Confidence 0.38 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC2072824 Disease Relevance 0.20 Pain Relevance 0
The group of conditions showing the closest association with specific HLA antigens are the "spondyloarthropathies."
HLA Binding (association) of
14) Confidence 0.38 Published 1982 Journal Ann. Clin. Lab. Sci. Section Abstract Doc Link 6950686 Disease Relevance 0.96 Pain Relevance 0.46
Ankylosing spondylitis and reactive arthritis triggered by either enteritis or urethritis are both associated with human leucocyte antigen (HLA) B27.
HLA Binding (associated) of in leucocyte associated with seronegative spondarthritis, spinal inflammation, enteritis, chlamydia infection and arthritis
15) Confidence 0.38 Published 1984 Journal Med. Biol. Section Abstract Doc Link 6088912 Disease Relevance 0.86 Pain Relevance 0.30
Celiac disease is associated with both human leukocyte antigen (HLA) and non-HLA genes and with other immune disorders, notably juvenile diabetes and thyroid disease.
HLA Binding (associated) of in thyroid associated with celiac disease, diabetes mellitus, thyroid disease and immune system diseases
16) Confidence 0.37 Published 1999 Journal Am. J. Clin. Nutr. Section Abstract Doc Link 10075317 Disease Relevance 1.69 Pain Relevance 0.11
Celiac disease is associated with both human leukocyte antigen (HLA) and non-HLA genes and with other immune disorders, notably juvenile diabetes and thyroid disease.
HLA Binding (associated) of in thyroid associated with celiac disease, diabetes mellitus, thyroid disease and immune system diseases
17) Confidence 0.37 Published 1999 Journal Am. J. Clin. Nutr. Section Abstract Doc Link 10075317 Disease Relevance 1.71 Pain Relevance 0.12
Ankylosing spondylitis (AS) has been associated with human leukocyte antigen (HLA)-B27 for over 30 years; however, the mechanism of action has remained elusive.
HLA Binding (associated) of in leukocyte associated with spinal inflammation
18) Confidence 0.37 Published 2007 Journal Genes Immun. Section Abstract Doc Link 17167495 Disease Relevance 0.60 Pain Relevance 0.60
These HLA associations are different from those reported in other inflammatory demyelinating diseases, including multiple sclerosis, optic neuritis, Guillain-Barré syndrome, and chronic relapsing inflammatory polyneuropathy.
HLA Binding (associations) of in optic associated with neuropathy, multiple sclerosis, inflammation, syndrome, optic neuritis, demyelinating disease and neuritis
19) Confidence 0.37 Published 1991 Journal J. Child Neurol. Section Abstract Doc Link 2045632 Disease Relevance 0.67 Pain Relevance 0.24
Several, but not all, genetic association studies have shown human leucocyte antigen (HLA)-A2, a major histocompatibility complex class I antigen-binding transmembrane protein has an increased frequency in AD compared to controls, and in some reports is associated with a lowered age of onset.
HLA Binding (associated) of in leucocyte associated with disease
20) Confidence 0.37 Published 2000 Journal Neurosci. Lett. Section Abstract Doc Link 11044581 Disease Relevance 0.72 Pain Relevance 0.14

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