INT193312

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Context Info
Confidence 0.74
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 1.88
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (DSPP) proteinaceous extracellular matrix (DSPP)
Anatomy Link Frequency
dentin 3
dentine 1
tooth 1
DSPP (Homo sapiens)
Pain Link Frequency Relevance Heat
anesthesia 4 98.60 Very High Very High Very High
Pain 17 86.12 High High
Inflammation 32 5.00 Very Low Very Low Very Low
Neuropeptide 4 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
potassium channel 2 5.00 Very Low Very Low Very Low
pulpitis 2 5.00 Very Low Very Low Very Low
adenocard 2 5.00 Very Low Very Low Very Low
chemokine 2 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 57 96.24 Very High Very High Very High
Tooth Demineralization 1 94.72 High High
Cleidocranial Dysplasia 171 92.72 High High
Dentinogenesis Imperfecta 258 91.40 High High
Injury 25 79.52 Quite High
Osteogenesis Imperfecta 45 69.12 Quite High
Obesity 9 62.64 Quite High
Pain 15 49.36 Quite Low
Necrosis 7 46.20 Quite Low
Dental Caries 13 43.44 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
DSPP is located within human chromosome 4q22.1 and consists of 5 exons spanning approximately 8343 bp [17]; however, see below for recent information regarding DSPP length polymorphisms affecting DPP.
Localization (located) of DSPP
1) Confidence 0.74 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2600777 Disease Relevance 1.40 Pain Relevance 0
At the mineralisation front, the collagenous component of the matrix is thought to provide the correct three-dimensional structure into which the mineral component of dentine is deposited while dentine phosphoprotein, which is secreted from cellular processes extending from the odontoblasts [14], is thought to act as a nucleator of hydroxyapatite crystals during the mineralisation process [12].
Localization (secreted) of dentine phosphoprotein in dentine
2) Confidence 0.69 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2600777 Disease Relevance 0 Pain Relevance 0
Overall, the mutations in DSPP that have been described to date consist of a combination of mis-sense and non-sense changes, splicing mutations and deletions (Table 1) which have been hypothesised to lead to intracellular retention of DSPP as a consequence of errors in signal peptide or subsequent processing events [2,26,27,31].
Localization (retention) of DSPP
3) Confidence 0.65 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2600777 Disease Relevance 0.06 Pain Relevance 0
Search terms included “sitagliptin”, “vildagliptin”, “saxagliptin”, “gliptin”, “incretin”, “dipeptidyl peptidase”, “DPP”, “LAF237”, and “MK-0431”.
Localization (dipeptidyl peptidase) of DPP
4) Confidence 0.27 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2597770 Disease Relevance 0.16 Pain Relevance 0
In addition, unwanted removal of sound dentin is avoided and the need for local anesthesia is less.
Localization (removal) of dentin in dentin associated with anesthesia
5) Confidence 0.06 Published 2010 Journal International Journal of Dentistry Section Body Doc Link PMC2862321 Disease Relevance 0 Pain Relevance 0.18
However, they could not accept the chemical theory of caries from acid demineralization of dentin under aseptic situations, as they placed a tooth in a closed flask with malic and butyric acid with human saliva in a meat suspension under aseptic conditions and no caries developed, finding uniform demineralization on all tooth surfaces, which did not resemble naturally occurring human caries, which was known to be more localized [51].

7.

Localization (localized) of dentin in tooth
6) Confidence 0.03 Published 2010 Journal International Journal of Dentistry Section Body Doc Link PMC2913523 Disease Relevance 0.09 Pain Relevance 0
A number of these growth factors are incorporated into the developing dentin matrix during initial tooth formation, forming a reservoir from which they can be released following dentin breakdown.
Localization (released) of dentin in dentin
7) Confidence 0.03 Published 2006 Journal Head Face Med Section Body Doc Link PMC1481630 Disease Relevance 0.15 Pain Relevance 0
Depending on a number of poorly defined factors, surviving post-mitotic odontoblastic cells can secrete tertiary dentin, a process known as reactionary or reparative dentinogenesis, or, alternatively, perivascular progenitor cells in the pulp can be triggered to differentiate into odontoblastic-like cells under the influence of specific growth factors [6,7].
Localization (secrete) of dentin in dentin
8) Confidence 0.03 Published 2006 Journal Head Face Med Section Body Doc Link PMC1481630 Disease Relevance 0 Pain Relevance 0

General Comments

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