INT193321

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Context Info
Confidence 0.02
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.34
Pain Relevance 2.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
spinal 2
T cell 1
Prh1 (Mus musculus)
Pain Link Frequency Relevance Heat
bradykinin 3 99.50 Very High Very High Very High
agonist 4 98.80 Very High Very High Very High
Glutamate 29 98.74 Very High Very High Very High
qutenza 51 98.08 Very High Very High Very High
nMDA receptor 27 95.00 High High
c fibre 33 94.16 High High
algogenic 3 90.68 High High
nMDA receptor antagonist 12 88.92 High High
antagonist 9 87.20 High High
chemokine 7 85.08 High High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 154 100.00 Very High Very High Very High
Nociception 33 100.00 Very High Very High Very High
Apoptosis 4 98.04 Very High Very High Very High
Alzheimer's Dementia 1 97.90 Very High Very High Very High
Adhesions 1 89.08 High High
Renal Disease 5 68.36 Quite High
Neuropathic Pain 12 65.80 Quite High
Pain 3 63.52 Quite High
Animal Disease Models 3 56.68 Quite High
Nervous System Injury 12 50.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast to type 1 and 2 nociception, type 3 nociception induced by prostaglandin I2 receptor agonists is mediated by capsaicin-insensitive fibers and spinal transmission through glutamate-NMDA receptors, possibly reflecting A?
Positive_regulation (induced) of type in spinal associated with nociception, glutamate, qutenza, nmda receptor and agonist
1) Confidence 0.02 Published 2006 Journal Mol Pain Section Body Doc Link PMC1482679 Disease Relevance 0.45 Pain Relevance 0.76
As type 3 nociception is mediated by capsaicin-insensitive fibers and glutamate-NMDA-receptor spinal transmission [5], the 250 Hz stimuli may activate at least type 3 fibers.
Positive_regulation (activate) of type in spinal associated with nociception, glutamate and qutenza
2) Confidence 0.02 Published 2006 Journal Mol Pain Section Body Doc Link PMC1482679 Disease Relevance 0.33 Pain Relevance 1.05
Type 1 is induced by bradykinin, SP or histamine, while type 2 is induced by ATP.
Positive_regulation (induced) of type associated with bradykinin
3) Confidence 0.02 Published 2006 Journal Mol Pain Section Body Doc Link PMC1482679 Disease Relevance 0.51 Pain Relevance 0.83
Peptide IAPP (islet amyloid polypeptide) 9-17 is one of the HLA-A*0201-restricted T cell epitopes in T1D patients [74], but IAPP is more of a type 2 diabetes risk factor in the process of ß cell apoptosis [75].
Positive_regulation (more) of type in T cell associated with diabetes mellitus, alzheimer's dementia and apoptosis
4) Confidence 0.01 Published 2008 Journal Current Genomics Section Body Doc Link PMC2685644 Disease Relevance 1.05 Pain Relevance 0.04

General Comments

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