INT19335

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.67
First Reported 1991
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 11
Total Number 12
Disease Relevance 9.82
Pain Relevance 2.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (CYC1) mitochondrion (CYC1) small molecule metabolic process (CYC1)
cytoplasm (CYC1)
Anatomy Link Frequency
neuronal 1
ligament 1
poly 1
acinar cells 1
CYC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 15 99.80 Very High Very High Very High
qutenza 12 98.08 Very High Very High Very High
opioid receptor 10 97.80 Very High Very High Very High
antagonist 1 95.24 Very High Very High Very High
Root ganglion neuron 2 90.50 High High
Kinase C 1 90.24 High High
Enkephalin 2 89.92 High High
analgesia 2 89.86 High High
Spinal cord 2 89.18 High High
chemokine 2 54.96 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 56 99.84 Very High Very High Very High
Hypoxia 13 99.82 Very High Very High Very High
Disease 229 98.64 Very High Very High Very High
Death 20 98.36 Very High Very High Very High
Stroke 7 96.86 Very High Very High Very High
Cancer 18 90.40 High High
Ganglion Cysts 2 90.34 High High
Frailty 2 89.32 High High
Brain Injury 2 88.78 High High
Toxicity 6 88.14 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The change of Psim by 50% was observed in the presence of CXCL10 in treated acinar cells along with enhanced expression of Cytochrome C, apaf-1 and caspase 9/3 activation.
Positive_regulation (activation) of Cytochrome C in acinar cells
1) Confidence 0.67 Published 2010 Journal Int J Exp Pathol Section Abstract Doc Link 20041963 Disease Relevance 1.11 Pain Relevance 0.08
NSAIDs and 5-FU induced the mitochondrial release of cytochrome c as well as caspase-3 and -9 activation, and to a much lesser extent, caspase-8.
Positive_regulation (activation) of cytochrome c associated with cinod
2) Confidence 0.49 Published 2002 Journal Cancer Res. Section Abstract Doc Link 12414664 Disease Relevance 1.04 Pain Relevance 0.30
NSAIDs and 5-FU induced the mitochondrial release of cytochrome c as well as caspase-3 and -9 activation, and to a much lesser extent, caspase-8.
Positive_regulation (induced) of cytochrome c associated with cinod
3) Confidence 0.49 Published 2002 Journal Cancer Res. Section Abstract Doc Link 12414664 Disease Relevance 1.06 Pain Relevance 0.30
The DOR-mediated HPC protection depended on an increase in ERK and Bcl 2 activity, which counteracted the SH-induced increase in p38 MAPK activities and cytochrome c release.
Positive_regulation (increase) of cytochrome c associated with hypoxia and opioid receptor
4) Confidence 0.49 Published 2005 Journal J. Biol. Chem. Section Abstract Doc Link 15687501 Disease Relevance 0.87 Pain Relevance 0.61
The protein levels of Bcl-2 decreased and Bax increased in the mitochondrial fraction while the Bax protein decreased, and p53 and cytochrome c protein levels increased in the cytosolic fraction in HepG2 cells after capsaicin treatment for 24 h by Western blot.
Positive_regulation (increased) of cytochrome c associated with qutenza
5) Confidence 0.45 Published 2009 Journal Anticancer Res. Section Abstract Doc Link 19331147 Disease Relevance 0.31 Pain Relevance 0.88
Further investigation showed that the cytochrome c pathway was responsible for NS398-induced apoptosis; i.e., cytochrome c was released from mitochondria, caspase-9 and caspase-3 were activated and finally poly(ADP-ribose)polymerase (PARP) was cleaved.
Positive_regulation (activated) of cytochrome c in poly associated with apoptosis
6) Confidence 0.45 Published 2001 Journal Int. J. Cancer Section Abstract Doc Link 11410869 Disease Relevance 1.13 Pain Relevance 0.22
COX-2-overexpressing cells showed reduced cytochrome c and caspase activation, relative to parental cells.
Positive_regulation (activation) of cytochrome c
7) Confidence 0.45 Published 2002 Journal Cancer Res. Section Abstract Doc Link 12414664 Disease Relevance 1.00 Pain Relevance 0.30
In the open configuration, cytochrome C and calcium are released into the cytoplasm, thus initiating caspase activation and irreversibly committing the cell to death (Basañez et al 1999; Wang 2001; Kokoszka et al 2004; Sharpe et al 2004).
Positive_regulation (activation) of cytochrome C associated with death
8) Confidence 0.45 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2376092 Disease Relevance 1.16 Pain Relevance 0
After transection of the left alar ligament, ranges of motion--due to 1.5 Nm torque--increased at both the C0-C1 and C1-C2 joints.
Positive_regulation (increased) of C0-C1 in ligament
9) Confidence 0.25 Published 1991 Journal J. Orthop. Res. Section Abstract Doc Link 2045985 Disease Relevance 0 Pain Relevance 0
In animal studies, low level near-infrared light therapy (LLLT) improved the outcome in retinal damage due to methanol or rotenone toxicity, [33-35] traumatic brain injury,[36] or spinal cord injury,[37] and induced analgesia in dorsal root ganglion neurons. [38] LLLT has improved the survival and function of rat neuronal cells exposed to MPP+ [39] or rotenone. [35] In the human brain, transcranial laser therapy (delivery of near-infrared laser light through the scalp and skull) has been used to successfully treat complex neurological conditions such as ischemic stroke. [40] Research supports the idea that near-infrared laser (750–1400 nm) light is absorbed and stimulates components in the mtETC, increases redox capacity, activates cytochrome c oxidase (complex IV), increases ATP production in dysfunctional cells and initiates long-term changes in neuronal function in human and animal studies. [37,40-43] Our results show that a single treatment with 810 nm laser light was sufficient to restore the velocity of mitochondrial movement to control levels in PD cybrid neuronal cells.


Positive_regulation (activates) of complex IV in neuronal associated with ganglion cysts, toxicity, stroke, root ganglion neuron, disease, brain injury, analgesia and spinal cord
10) Confidence 0.07 Published 2009 Journal Mol Neurodegener Section Body Doc Link PMC2711937 Disease Relevance 1.03 Pain Relevance 0.23
Reduced complex IV activity and increased levels of nitrated proteins have been detected in PD tissue and in PD cybrid lines[24,27].
Positive_regulation (increased) of complex IV associated with disease
11) Confidence 0.06 Published 2009 Journal Mol Neurodegener Section Body Doc Link PMC2711937 Disease Relevance 0.99 Pain Relevance 0
The electrons then flow via coenzyme Q (ubiquinone) to complex III, and are then transported via cytochrome C to reach complex IV (cytochrome oxidase).
Positive_regulation (reach) of complex IV
12) Confidence 0.01 Published 2006 Journal Crit Care Section Body Doc Link PMC1751057 Disease Relevance 0.11 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox