INT193361

Context Info Confidence 0.41 First Reported 2006 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 0.79 Pain Relevance 0

nucleus (SHOX)

Anatomy Link Frequency brain 2 SHOX (Homo sapiens)

Pain Link Frequency Relevance Heat Action potential 5 5.00 agonist 4 5.00 medulla 4 5.00 Migraine 3 5.00 depression 2 5.00 Pain 2 5.00 headache 2 5.00 cerebral cortex 1 5.00 repetitive firing 1 5.00 Multiple sclerosis 1 5.00

Disease Link Frequency Relevance Heat Growth Problems 100 98.38 Congenital Anomalies 2 82.76 Syndrome 2 79.44 Turner's Syndrome 2 75.40 Immunodeficiency 1 69.36 Growth Hormone Deficiency 7 5.00 Headache 5 5.00 Hypoglycemia 4 5.00 Cognitive Disorder 3 5.00 Depression 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In an analysis of 68 patients with ISS, one female patient was identified who had a normal karyotype but a deletion of one SHOX allele.69

Positive_regulation (one) of Gene_expression (allele.69) of SHOX associated with growth problems

1) Confidence 0.41 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2898102 Disease Relevance 0.79 Pain Relevance 0

4) If the usual practice in SS analysis were done, namely that only the product at the frequency of stimulationis used, then the data obtained from the 6 runs at the bottom of Fig. 26would show marked variation in amplitude even though the actual brain response is the same in every run!

Positive_regulation (practice) of Gene_expression (analysis) of SS in brain

2) Confidence 0.18 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1483834 Disease Relevance 0 Pain Relevance 0

General Comments

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