INT193405

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Context Info
Confidence 0.53
First Reported 2006
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 14
Total Number 16
Disease Relevance 3.33
Pain Relevance 1.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
juvenile 2
medial 2
lateral 1
arm 1
OFC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Anterior cingulate cortex 810 99.92 Very High Very High Very High
Pain 11 97.76 Very High Very High Very High
Anterior cingulate 6 96.88 Very High Very High Very High
Hippocampus 59 84.60 Quite High
depression 56 63.16 Quite High
Nucleus accumbens 23 10.48 Low Low
amygdala 29 7.76 Low Low
imagery 25 5.00 Very Low Very Low Very Low
alcohol 16 5.00 Very Low Very Low Very Low
isoflurane 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Aggression 230 99.24 Very High Very High Very High
Pain 9 97.76 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 45 94.96 High High
Anxiety Disorder 212 94.84 High High
Stress 11 90.32 High High
Unconsciousness 56 83.60 Quite High
Depression 72 63.16 Quite High
Personality Disorder 3 19.56 Low Low
Cognitive Disorder 53 5.00 Very Low Very Low Very Low
Repression 40 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study we show that the medial OFC responds to reward outcomes (as well as following successful avoidance of aversive outcomes), whereas both medial and lateral OFC responds during anticipation of reward.
Gene_expression (responds) of OFC in medial
1) Confidence 0.53 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1484497 Disease Relevance 0 Pain Relevance 0
The main finding of this study is that the medial OFC responds during successful avoidance of aversive outcome as well as during receipt of explicit rewards.
Gene_expression (responds) of OFC in medial
2) Confidence 0.53 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1484497 Disease Relevance 0.17 Pain Relevance 0.17
Conversely, Cg25 was found to be strongly connected with regions of the DMN such as the OFC.
Gene_expression (regions) of OFC
3) Confidence 0.32 Published 2008 Journal Ann Gen Psychiatry Section Body Doc Link PMC2515304 Disease Relevance 0.20 Pain Relevance 0.29
There is also a striking similarity in the changes in emotional responsivity following OFC lesions in rats and macaques.
Gene_expression (lesions) of OFC
4) Confidence 0.19 Published 2007 Journal The European Journal of Neuroscience Section Body Doc Link PMC2228395 Disease Relevance 0.64 Pain Relevance 0.03
The observation from the present study that OFC lesions do not affect the amount of social behaviour, or the utilization of social information, suggests that the deficit in STFP with OFC lesions is not due to the social context of the experiment.
Gene_expression (lesions) of OFC
5) Confidence 0.19 Published 2007 Journal The European Journal of Neuroscience Section Body Doc Link PMC2228395 Disease Relevance 0.52 Pain Relevance 0.09
Bonferroni tests comparing the amount of aggressive behaviour between lesion groups confirmed that OFC lesion animals were significantly more aggressive than both ACC (P < 0.05) and sham lesion animals (P < 0.01).
Gene_expression (aggressive) of OFC associated with aggression and anterior cingulate cortex
6) Confidence 0.19 Published 2007 Journal The European Journal of Neuroscience Section Body Doc Link PMC2228395 Disease Relevance 0.15 Pain Relevance 0.14
To investigate these issues, rats with either ACC or OFC lesions were tested on a number of previously validated ethological, unconditioned tests of social interaction and emotionality (Bannerman et al., 2002b; McHugh et al., 2004).
Gene_expression (lesions) of OFC associated with anterior cingulate cortex
7) Confidence 0.19 Published 2007 Journal The European Journal of Neuroscience Section Body Doc Link PMC2228395 Disease Relevance 0.07 Pain Relevance 0.28
Although OFC lesions did not diminish animals' social engagement, they led to a small but significant increase in aggression (Fig. 4), and decreased fear in response to unconditioned stimuli on the hyponeophagia test (Fig. 7).
Gene_expression (lesions) of OFC associated with anxiety disorder and aggression
8) Confidence 0.19 Published 2007 Journal The European Journal of Neuroscience Section Body Doc Link PMC2228395 Disease Relevance 0.27 Pain Relevance 0
The observation from the present study that OFC lesions do not affect the amount of social behaviour, or the utilization of social information, suggests that the deficit in STFP with OFC lesions is not due to the social context of the experiment.
Gene_expression (lesions) of OFC
9) Confidence 0.19 Published 2007 Journal The European Journal of Neuroscience Section Body Doc Link PMC2228395 Disease Relevance 0.46 Pain Relevance 0.16
Subsequent analysis showed that whereas both the sham (F1,22 = 17.78; P < 0.001) and OFC (F1,17 = 11.22; P < 0.005) lesioned rats showed a significantly higher level of investigation for a novel juvenile compared with that for a familiar juvenile, this was not the case for the ACC lesioned rats (F1,21 < 1; P > 0.20).
Gene_expression (lesioned) of OFC in juvenile associated with anterior cingulate cortex
10) Confidence 0.19 Published 2007 Journal The European Journal of Neuroscience Section Body Doc Link PMC2228395 Disease Relevance 0 Pain Relevance 0.13
Control and OFC groups showed less interest when the same juvenile was presented again, either immediately after the first encounter (Fig. 2C) or after delay (Fig. 2A), but they continued to engage in a high rate of socially orientated investigative behaviours when the identity of the juvenile was changed (Fig. 2B).
Gene_expression (groups) of OFC in juvenile
11) Confidence 0.19 Published 2007 Journal The European Journal of Neuroscience Section Body Doc Link PMC2228395 Disease Relevance 0.19 Pain Relevance 0.03
In the present study we show that the medial OFC responds to reward outcomes (as well as following successful avoidance of aversive outcomes), whereas both medial and lateral OFC responds during anticipation of reward.
Gene_expression (responds) of OFC in lateral
12) Confidence 0.18 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1484497 Disease Relevance 0 Pain Relevance 0
For example, there is the intriguing possibility that both lesions result in impulsivity, but that dHPC lesions do so through an inability to withhold from executing an inappropriate response (behavioral disinhibition), whereas vHPC lesioned animals are unable to properly value delayed rewards, possibly as a consequence of disrupting HPC-OFC connections.
Gene_expression (connections) of OFC associated with attention deficit hyperactivity disorder
13) Confidence 0.03 Published 2008 Journal Behav Neurosci Section Body Doc Link PMC2671844 Disease Relevance 0.24 Pain Relevance 0.03
However, the effect of dHPC lesions on this task was not necessarily as predicted on the basis of the anatomical segregation of HPC-OFC connections.
Gene_expression (connections) of OFC
14) Confidence 0.03 Published 2008 Journal Behav Neurosci Section Body Doc Link PMC2671844 Disease Relevance 0.18 Pain Relevance 0.08
Compared to controls, rats with OFC lesions display an increased preference for the goal arm of a T maze containing an immediately available low reward (LR) over the goal arm containing a higher reward (HR) that is only available after a delay (Rudebeck, Walton, Smyth, Bannerman, & Rushworth, 2006).
Gene_expression (lesions) of OFC in arm
15) Confidence 0.03 Published 2008 Journal Behav Neurosci Section Body Doc Link PMC2671844 Disease Relevance 0 Pain Relevance 0
As controls, 11 patients with both luteal phase defect and high CL-RI (?
Gene_expression (defect) of CL-RI
16) Confidence 0.03 Published 2009 Journal J Ovarian Res Section Body Doc Link PMC2633338 Disease Relevance 0.24 Pain Relevance 0

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