INT19341

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Context Info
Confidence 0.59
First Reported 1991
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 8
Disease Relevance 6.40
Pain Relevance 0.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
MALT 2
central nervous system 1
T-cell 1
IGH@ (Homo sapiens)
Pain Link Frequency Relevance Heat
Central nervous system 71 99.16 Very High Very High Very High
Multiple sclerosis 5 90.04 High High
anesthesia 1 87.04 High High
Inflammation 11 81.96 Quite High
headache 11 79.84 Quite High
Pain 1 52.40 Quite High
imagery 10 26.48 Quite Low
abdominal pain 2 21.28 Low Low
vincristine 2 14.32 Low Low
Spinal cord 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 66 99.90 Very High Very High Very High
Lymphatic System Cancer 259 98.16 Very High Very High Very High
Congenital Anomalies 2 96.08 Very High Very High Very High
Frailty 1 95.24 Very High Very High Very High
Acute Renal Failure 1 93.28 High High
Demyelinating Disease 7 90.04 High High
Generaliased Trisomy 10 89.64 High High
Lymphadenopathy 5 85.44 High High
Cranial Neuropathy 1 82.36 Quite High
INFLAMMATION 11 81.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IgM, IgA, and IgG indexes (indicators of intratechal immunglobulin synthesis) decreased when the central nervous system events subsided after successful treatment but the CT abnormalities (e. g. atrophy) were not altered.
Gene_expression (synthesis) of immunglobulin in central nervous system associated with congenital anomalies, frailty and central nervous system
1) Confidence 0.59 Published 1991 Journal Orv Hetil Section Abstract Doc Link 2047115 Disease Relevance 0.72 Pain Relevance 0.28
In conclusion, we report a rare case of primary dural MALT lymphoma with prominent plasmacytic differentiation and the diagnosis was confirmed by a monoclonal IgH gene rearrangement and a positive MALT1 rearrangement involving IgH and MALT1 on chromosome 14 and 18, respectively.



Gene_expression (rearrangement) of IgH in MALT associated with lymphatic system cancer
2) Confidence 0.32 Published 2008 Journal J Hematop Section Body Doc Link PMC2713483 Disease Relevance 0.61 Pain Relevance 0
The normal IgH and MALT1 loci are represented by the single red and single green signals respectively (×100)
Gene_expression (normal) of IgH
3) Confidence 0.32 Published 2008 Journal J Hematop Section Body Doc Link PMC2713483 Disease Relevance 0.86 Pain Relevance 0
In conclusion, we report a rare case of primary dural MALT lymphoma with prominent plasmacytic differentiation and the diagnosis was confirmed by a monoclonal IgH gene rearrangement and a positive MALT1 rearrangement involving IgH and MALT1 on chromosome 14 and 18, respectively.



Gene_expression (rearrangement) of IgH in MALT associated with lymphatic system cancer
4) Confidence 0.32 Published 2008 Journal J Hematop Section Body Doc Link PMC2713483 Disease Relevance 0.68 Pain Relevance 0
The normal IgH and MALT1 loci are represented by the single red and single green signals respectively (×100)
Gene_expression (loci) of IgH
5) Confidence 0.32 Published 2008 Journal J Hematop Section Body Doc Link PMC2713483 Disease Relevance 0.87 Pain Relevance 0
The tumor was negative for clonal IgH gene by PCR using the primers to VH framework III and JH regions.
Neg (negative) Gene_expression (negative) of IgH associated with cancer
6) Confidence 0.25 Published 2008 Journal J Hematop Section Body Doc Link PMC2713483 Disease Relevance 0.92 Pain Relevance 0
Association and/or linkage studies to candidate genes have produced many reports of significant genetic effects including those for the major histocompatability complex (MHC; particularly the HLA-DR2 allele), immunoglobulin heavy chain (IgH), T-cell receptor (TCR) and myelin basic protein (MBP) loci.
Gene_expression (produced) of IgH in T-cell
7) Confidence 0.06 Published 1996 Journal Nat. Genet. Section Abstract Doc Link 8696344 Disease Relevance 0.64 Pain Relevance 0.37
FISH study was positive for gene rearrangement of bcl-6, and fusions of myc, IgH, and bcl-2 (Fig. 2).
Gene_expression (fusions) of IgH
8) Confidence 0.04 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1904237 Disease Relevance 1.10 Pain Relevance 0.05

General Comments

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