INT19342

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Context Info
Confidence 0.24
First Reported 1991
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 6.11
Pain Relevance 1.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Insr) endosome (Insr) plasma membrane (Insr)
nucleus (Insr) kinase activity (Insr)
Anatomy Link Frequency
macrophages 2
plasma 1
muscle 1
skeletal muscle 1
striatum 1
Insr (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 64 99.84 Very High Very High Very High
Inflammation 88 94.40 High High
tolerance 36 93.52 High High
antagonist 3 93.32 High High
adenocard 5 88.72 High High
Pain 3 83.68 Quite High
Antinociceptive 4 75.00 Quite High
opiate 2 75.00 Quite High
chemokine 10 74.32 Quite High
cytokine 35 73.72 Quite High
Disease Link Frequency Relevance Heat
Insulin Resistance 78 100.00 Very High Very High Very High
Frailty 49 100.00 Very High Very High Very High
Stress 23 100.00 Very High Very High Very High
Hypopituitarism 15 98.76 Very High Very High Very High
Cataract 4 98.56 Very High Very High Very High
Hyperinsulinism 13 97.68 Very High Very High Very High
Atherosclerosis 10 96.80 Very High Very High Very High
Disease 143 96.68 Very High Very High Very High
Obesity 262 95.16 Very High Very High Very High
Apoptosis 38 95.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To this end, macrophages were isolated from the bone marrow of control- and IR?
Regulation (isolated) of IR in macrophages
1) Confidence 0.24 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2865520 Disease Relevance 0.97 Pain Relevance 0.11
Furthermore, MBNL1 has been shown to bind directly to intronic elements of genes misregulated in DM cardiac and skeletal muscle (cTNT and IR) and to promote alternative splicing patterns normally found in adult tissue [21].
Regulation (misregulated) of IR in skeletal muscle associated with frailty
2) Confidence 0.20 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2719092 Disease Relevance 1.07 Pain Relevance 0
Taking that into account, our results underline the important role of insulin receptor-dependent regulation of MMP-9 in macrophages and further extend it to another hyperinsulinemia-related disease state i.e. the development of obesity-associated inflammation and insulin resistance.
Regulation (regulation) of insulin receptor in macrophages associated with inflammation, obesity, metalloproteinase, hyperinsulinism, insulin resistance and disease
3) Confidence 0.17 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2865520 Disease Relevance 0.94 Pain Relevance 0.44
Similar to the dysregulation of other genes in DM1 (CLCN-1, IR) [5], the expression of CUGexp but not CAGexp transcripts [37] triggers a shift in the ratios of alternatively spliced GABT4 transcripts that resembles those found during fetal development.
Regulation (dysregulation) of IR
4) Confidence 0.13 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2719092 Disease Relevance 0.25 Pain Relevance 0.03
Effect of acute ethanol challenge on insulin receptor, PPAR-?
Regulation (Effect) of insulin receptor
5) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890411 Disease Relevance 0.15 Pain Relevance 0.08
Consistent with the involvement of MBNL proteins in the RNA gain of function mechanism, Mbnl1 knockdown mice [60] showed DM1-like phenotypes including iridescent cataracts, myotonia and missplicing of muscle transcripts that had been reported altered in DM1 patients such as IR and CLC-1 pre-mRNA [61, 62]. muscleblind mutant embryos similarly showed altered expression of muscle transcript isoforms from the Drosophila ZASP homologue and alpha-actinin genes [63].
Regulation (altered) of IR in muscle associated with hypopituitarism and cataract
6) Confidence 0.09 Published 2008 Journal Current Genomics Section Body Doc Link PMC2694559 Disease Relevance 0.38 Pain Relevance 0
Berberine, as a natural plant alkaloid isolated from the Coptis chinens, has been noted for its potential glucose lowering effect[15].

• Influence on insulin resistance(IR) and serum insulin: JQJT tablets can improve the insulin resistance caused by Hydrocortisone and decrease the serum insulin in mice[16]. • Influence on immune function: JQJT tablets can improve immune function and protect thymus gland atrophy of mice [16].


Regulation (Influence) of insulin associated with frailty and insulin resistance
7) Confidence 0.08 Published 2010 Journal Trials Section Body Doc Link PMC2842259 Disease Relevance 0.83 Pain Relevance 0.07
Chronic treatment with alprazolam reversed the effect of acute stress on the concentration of immunoreactive beta-endorphin (IR-BE) in the anterior pituitary (AP) and increased the amount of beta-endorphin (BE) relative to beta-lipotropin (B-LPH).
Regulation (effect) of IR-BE in anterior pituitary associated with stress
8) Confidence 0.07 Published 1991 Journal Res. Commun. Chem. Pathol. Pharmacol. Section Abstract Doc Link 2047572 Disease Relevance 0.29 Pain Relevance 0.18
In chronically stressed animals, administration of alprazolam did not alter the effect of a single stressful episode on the concentration of IR-BE in the AP, the NIL or the plasma, however, the amount of BE relative to B-LPH was increased in the AP and the plasma.
Regulation (effect) of IR-BE in plasma
9) Confidence 0.06 Published 1991 Journal Res. Commun. Chem. Pathol. Pharmacol. Section Abstract Doc Link 2047572 Disease Relevance 0.40 Pain Relevance 0.23
Glucose metabolism and insulin receptor mediated signal transduction control the activity of several enzymes involved in the generation of the APP derivative A?
Regulation (control) of insulin receptor
10) Confidence 0.04 Published 2010 Journal The Open Biochemistry Journal Section Body Doc Link PMC2864432 Disease Relevance 0.40 Pain Relevance 0.07
MA-induced increases in activator protein (AP)-1 DNA binding activity, Fos-related antigen immunoreactivity (FRA-IR), proenkephalin mRNA expression, and proenkephalin-like immunoreactivity were reduced consistently in the striatum of animals that were pretreated with ginsenosides.
Regulation (immunoreactivity) of FRA-IR in striatum
11) Confidence 0.04 Published 2005 Journal Behav. Brain Res. Section Abstract Doc Link 15680202 Disease Relevance 0 Pain Relevance 0.29
Moreover, although insulin secretory response 30 min after glucose injection appeared adequate in bIGF1RKO+/?
Regulation (response) of insulin
12) Confidence 0.03 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2573928 Disease Relevance 0.42 Pain Relevance 0.05

General Comments

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