INT193437

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Context Info
Confidence 0.48
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 19
Disease Relevance 0.68
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

MCO (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 180 22.08 Low Low
Paracetamol 16 5.00 Very Low Very Low Very Low
Patient controlled alalgesia 16 5.00 Very Low Very Low Very Low
Opioid 16 5.00 Very Low Very Low Very Low
Central nervous system 6 5.00 Very Low Very Low Very Low
Perioperative pain 4 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
Bile 4 5.00 Very Low Very Low Very Low
abdominal pain 2 5.00 Very Low Very Low Very Low
analgesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Critical Illness 3 96.94 Very High Very High Very High
Pneumonia 34 91.80 High High
Acute Cholecystitis 56 86.80 High High
Postoperative Complications 60 80.04 Quite High
Sepsis 16 46.36 Quite Low
Convalescence 20 28.80 Quite Low
Pain 180 22.08 Low Low
Vomiting 80 20.08 Low Low
Stress 34 15.28 Low Low
Myocardial Infarction 2 12.72 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In our data, the impact of LC use on the reduction of LOS was small.
Negative_regulation (reduction) of LOS
1) Confidence 0.48 Published 2006 Journal BMC Health Serv Res Section Body Doc Link PMC1488841 Disease Relevance 0.08 Pain Relevance 0
Reflecting this policy, the studied hospitals had a remarkably long overall preoperative hospital stay; the mean preoperative LOS was 17.1 days, and the institutional means ranged from 8.0 to 21.3 days; however, if the policy of early surgery were to be universally applied, we consider that the overall LOS would be reduced by more than 10 days.
Negative_regulation (reduced) of LOS
2) Confidence 0.48 Published 2006 Journal BMC Health Serv Res Section Body Doc Link PMC1488841 Disease Relevance 0.09 Pain Relevance 0
When we estimated the reduction in LOS between groups, we used multivariate analysis in order to adjust for potential differences in the most important covariates to get the most precise estimate.
Negative_regulation (reduction) of LOS
3) Confidence 0.30 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2396162 Disease Relevance 0 Pain Relevance 0
Compared to that result, we observed a significant further reduction in adjusted crude LOS of 0.8 (95% CI, 0.2 – 1.7), favoring the postimplementation period (P = 0.031).
Negative_regulation (reduction) of LOS
4) Confidence 0.30 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2396162 Disease Relevance 0 Pain Relevance 0
The observed difference in LOS therefore consisted of two elements, which we considered to be equally important parts of our accelerated intervention, namely a reduction in LOS due to changed admission procedures in the multi-disciplinary organization, and a reduction in LOS due to changed multi-modal intervention.
Negative_regulation (reduction) of LOS
5) Confidence 0.30 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2396162 Disease Relevance 0 Pain Relevance 0
We have further documented that LOS could be markedly reduced without increasing mortality and morbidity.
Negative_regulation (reduced) of LOS
6) Confidence 0.30 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2396162 Disease Relevance 0.18 Pain Relevance 0
The observed reduction in LOS from preimplementation period to postimplementation period in our study is in accordance with three of the four published efficacy studies [19-21], but in conflict with the study by Petersen et. al [22].
Negative_regulation (reduction) of LOS
7) Confidence 0.30 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2396162 Disease Relevance 0 Pain Relevance 0
We believe the omission of this criterion has led to a reduction in LOS of approximately 1.5 days, because LOS for TKA in our RCT [19], in which the intervention was identical but the criterion was included had a LOS of 6.1 days, whereas LOS was 4.7 days in the postimplementation period, in which this criterion was omitted.
Negative_regulation (reduction) of LOS
8) Confidence 0.30 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2396162 Disease Relevance 0 Pain Relevance 0
Crude LOS in the postimplementation period for the patients receiving the accelerated intervention was reduced to 4.0 days (SD 1.7) for the THA patients and 4.7 days (SD 1.7) for the TKA patients.
Negative_regulation (reduced) of LOS
9) Confidence 0.30 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2396162 Disease Relevance 0 Pain Relevance 0
The crude adjusted average reduction in LOS when excluding the 15 patients admitted on a Friday was 4.2 days (95% CI 3.7 – 4.9) (P < 0.001).
Negative_regulation (reduction) of LOS
10) Confidence 0.30 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2396162 Disease Relevance 0 Pain Relevance 0
We observed a crude adjusted average reduction in LOS of 4.4 days (95% CI 3.8 – 5.0) from a LOS of 8.8 days (SD 3.0) for all patients receiving the current procedure in the preimplementation period to 4.3 days (SD 1.8) for all patients receiving the fully implemented accelerated intervention in the postimplementation period (P < 0.001).
Negative_regulation (reduction) of LOS
11) Confidence 0.30 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2396162 Disease Relevance 0 Pain Relevance 0
This observation is in line with the results presented in the RCT by Dowsey et al., in which they reported a large reduction in LOS in both the intervention and control groups compared to the period just prior to the study period [20].
Negative_regulation (reduction) of LOS
12) Confidence 0.30 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2396162 Disease Relevance 0 Pain Relevance 0
The observed difference in LOS therefore consisted of two elements, which we considered to be equally important parts of our accelerated intervention, namely a reduction in LOS due to changed admission procedures in the multi-disciplinary organization, and a reduction in LOS due to changed multi-modal intervention.
Negative_regulation (reduction) of LOS
13) Confidence 0.30 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2396162 Disease Relevance 0 Pain Relevance 0
But in our RCT, we observed a reduction in LOS because of a change in the organization of admission procedures to account for a mean reduction of 1.5 days [19], and we have shown that this result also applies to this study.
Negative_regulation (reduction) of LOS
14) Confidence 0.22 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2396162 Disease Relevance 0 Pain Relevance 0
We believe that the observed reduction in adjusted LOS of 4.4 days between the preimplementation period and the postimplementation period was achieved by contribution from both parts of our accelerated intervention (i.e. changes in multi-disciplinary organization and multi-modal intervention).
Negative_regulation (reduction) of LOS
15) Confidence 0.22 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2396162 Disease Relevance 0.16 Pain Relevance 0
The crude adjusted average reduction in postoperative LOS was 3.1 days (95% CI 2.6 – 3.7) (P < 0.001).
Negative_regulation (reduction) of LOS
16) Confidence 0.22 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2396162 Disease Relevance 0 Pain Relevance 0
Mean LOS was significantly (P < 0.001) reduced by 4.4 (95% CI 3.8–5.0) days after implementation of the accelerated intervention, from 8.8 (SD 3.0) days before implementation to 4.3 (SD 1.8) days after implementation.
Negative_regulation (reduced) of LOS
17) Confidence 0.22 Published 2008 Journal BMC Musculoskelet Disord Section Abstract Doc Link PMC2396162 Disease Relevance 0 Pain Relevance 0
We observed a crude adjusted average reduction in LOS of 4.4 days (95% CI 3.8 – 5.0) from a LOS of 8.8 days (SD 3.0) for all patients receiving the current procedure in the preimplementation period to 4.3 days (SD 1.8) for all patients receiving the fully implemented accelerated intervention in the postimplementation period (P < 0.001).
Negative_regulation (reduction) of LOS
18) Confidence 0.22 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2396162 Disease Relevance 0 Pain Relevance 0
Data on the outcome of critically ill patients with low ScvO2 are rare [19], and so far, no study has demonstrated that ScvO2-guided treatment can reduce mortality in ICU patients, although LOS has been decreased in cardiac surgery patients using SvO2 as a parameter for increasing systemic oxygen supply [3].
Negative_regulation (decreased) of LOS associated with critical illness
19) Confidence 0.01 Published 2007 Journal Crit Care Section Body Doc Link PMC2151877 Disease Relevance 0.18 Pain Relevance 0

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