INT193451

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Context Info
Confidence 0.02
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 1.75
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Sdha) mitochondrion (Sdha) oxidoreductase activity (Sdha)
Anatomy Link Frequency
motor neurons 1
Sdha (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 30 99.10 Very High Very High Very High
adenocard 4 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Drug Induced Neurotoxicity 2 99.12 Very High Very High Very High
Toxicity 8 98.18 Very High Very High Very High
Parkinson's Disease 12 89.08 High High
Disease 20 87.24 High High
Targeted Disruption 34 79.92 Quite High
Motor Neuron Diseases 54 77.84 Quite High
Death 36 72.76 Quite High
Aging 6 66.76 Quite High
Neurodegenerative Disease 4 26.40 Quite Low
Apoptosis 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Consistent with a Complex I bypass hypothesis, we found that DHB overcomes the toxicity elicited by rotenone in SOD1 G93A spinal cord motor neurons but is unable to overcome the inhibition of the mitochondrial Complex II by malonate.
Negative_regulation (inhibition) of Complex II in motor neurons associated with toxicity and spinal cord
1) Confidence 0.02 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1488864 Disease Relevance 0.57 Pain Relevance 0.12
DBH prevented rotenone mediated inhibition of mitochondrial complex I but not malonate inhibition of complex II.
Negative_regulation (inhibition) of complex II
2) Confidence 0.02 Published 2006 Journal BMC Neurosci Section Abstract Doc Link PMC1488864 Disease Relevance 1.18 Pain Relevance 0.05

General Comments

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