INT193466

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Context Info
Confidence 0.27
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.62
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (Acta1) cytoplasm (Acta1)
Acta1 (Mus musculus)
Pain Link Frequency Relevance Heat
aspirin 9 82.24 Quite High
alcohol 1 55.28 Quite High
antagonist 1 54.36 Quite High
Inflammation 3 19.04 Low Low
pruritus 4 17.20 Low Low
cva 17 5.00 Very Low Very Low Very Low
ischemia 10 5.00 Very Low Very Low Very Low
Bioavailability 3 5.00 Very Low Very Low Very Low
abdominal pain 3 5.00 Very Low Very Low Very Low
headache 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Malaria 171 99.24 Very High Very High Very High
Acute Coronary Syndrome 27 99.00 Very High Very High Very High
Spontaneous Abortion 4 98.88 Very High Very High Very High
Sprains And Strains 18 98.68 Very High Very High Very High
Toxicity 5 95.84 Very High Very High Very High
Hemorrhage 42 90.92 High High
Recurrence 24 85.44 High High
Stroke 4 84.96 Quite High
Myocardial Infarction 23 84.64 Quite High
Disease 12 81.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The WHO currently recommends four ACTs for uncomplicated malaria; AS+mefloquine, which is impractical for Africa due to high cost and risk of toxicity; AS+sulfadoxine/pyrimethamine (SP), which showed unacceptably poor efficacy in Uganda [24], probably due to frequent parasite resistance to SP; AS+AQ, and AL.
ACTs Binding (recommends) of associated with malaria and toxicity
1) Confidence 0.27 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2405936 Disease Relevance 0.47 Pain Relevance 0.03
In Southeast Asia, ACTs have been highly efficacious and associated with reductions in morbidity, gametocyte carriage, and malaria transmission [3,4].
ACTs Binding (associated) of associated with malaria
2) Confidence 0.07 Published 2006 Journal PLoS Clinical Trials Section Body Doc Link PMC1488893 Disease Relevance 0.43 Pain Relevance 0
WHO currently recommends ACTs as the primary treatment for most strains of malaria and for most patients with the exception of pregnant women in their first trimester [9].


ACTs Binding (recommends) of associated with malaria and sprains and strains
3) Confidence 0.02 Published 2010 Journal The Yale Journal of Biology and Medicine Section Body Doc Link PMC3002152 Disease Relevance 0.66 Pain Relevance 0
Heparin acts via binding and catalyzing the activity of AT.
acts Binding (binding) of
4) Confidence 0.01 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2515410 Disease Relevance 0.72 Pain Relevance 0.20
ACTs are associated with embryotoxicity over a narrow dose range in animal models of early pregnancy with some additional evidence of lethality in second and third trimesters [82].
ACTs Binding (associated) of
5) Confidence 0.01 Published 2008 Journal Malar J Section Body Doc Link PMC2632633 Disease Relevance 0.34 Pain Relevance 0

General Comments

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